Roomi MW, Netke SP, Ivanov V, Niedzwiecki A, Rath M.
American College of Nutrition, 42nd Annual Meeting, Orlando, Florida, Oct. 3-7, 2001.
Journal of the American College of Nutrition, 22 (5):575, Abstract #43, October 2001.
Ascorbic acid and its derivatives have been shown to be cytotoxic and inhibit the growth of a number of malignant and non-malignant cell lines in culture and in animal models. In this study, ascorbic acid, which is water-soluble, was not toxic to the melanoma and liver cancer lines tested; however, the lipophilic (lipid soluble) derivatives studied were found to be markedly toxic to these cell lines. This implies that these lipid-soluble derivatives, which can cross cell membranes and the blood brain barrier, have therapeutic potential in the treatment of cancer.