M.W. Roomi, N. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
Experimental Lung Research 2006, 32(10):517-530.
Tumor metastasis is a major reason for treatment failure in cancer patients. Melanoma is one of the types of cancer that most frequently metastasize, especially in the lung. Currently used therapies are ineffective with a high level of toxicity and mortality.Cancer metastasis is accompanied by degradation of connective tissue necessary to facilitate the spread and invasion of cancer cells from one organ to other parts of the body.