Lung Cancer

A Novel Nutrient Mixture Induces Apoptosis in Human Mesothelioma Cells (MSTO-211H) via Activation of Caspases

M.Waheed Roomi, Bilwa Bhanap, Aleksandra Niedzwiecki* and Matthias Rath
Dr Rath Research Institute, Santa Clara, CA
Glob J Cancer Ther 5(1): 007-011. DOI: https://dx.doi.org/10.17352/2581-5407.000024

Abstract
Malignant mesothelioma is a highly aggressive and fatal cancer of older people. Consistently associated with asbestos exposure, mesothelioma is diagnosed when it is extensively metastasized and it has a dismal prognosis.

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Modulation of u-PA, MMPs and their inhibitors by a novel nutrient mixture in human lung cancer and mesothelioma cell lines

M.Waheed Roomi, Tatiana Kalinovsky, Aleksandra Niedzwiecki* and Matthias Rath
Dr Rath Research Institute, Santa Clara, CA
International Journal of Oncology 2013, DOI: 10.3892/ijo.2013.1880

Abstract
Lung cancer, the most prevalent cancer worldwide, and malignant mesothelioma are highly aggressive tumors that are characterized by high levels of matrix metalloproteinase (MMP)-2 and -9 secretion. Proteases play a key role in tumor cell invasion and metastasis by digesting the basement membrane and ECM components. Strong clinical and experimental evidence demonstrates association of elevated levels of u-PA and MMPs with cancer progression, metastasis and shortened patient survival. MMP activities are regulated by specific tissue inhibitors of metalloproteinases (TIMPS).

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Modulation of MMP-2 and MMP-9 by cytokines, mitogens and inhibitors in lung cancer and malignant mesothelioma cell lines

M.W. Roomi, J.C. Monterrey, T. Kalinovsky, A. Niedzwiecki and M. Rath
Oncology Reports 2009; 22(6):1283-1291

Abstract:
Matrix metalloproteinases (MMPs) secreted by lung cancer (LC) and malignant mesothelioma (MM), especially MMP-2 and MMP-9, play crucial roles in tumor invasion and metastasis. We examined the effect of cytokines, mitogens, and inhibitors on MMP-2 and MMP-9 expression in LC and MM cell lines. Human LC (A-549) and MM (MSTO-211H) cell lines were cultured in appropriate media.

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Chemopreventive effect of a novel nutrient mixture on lung tumorigenesis induced by urethane in male A/J mice

M.W. Roomi, N.W. Roomi, T. Kalinovsky, M. Rath and A. Niedzwiecki

Tumori 2009; 95(4): 508-513

Abstract:
Lung cancer, a leading cause of cancer death, is associated with exposure to inhalation carcinogens, most commonly those found in tobacco smoke. We investigated the in vivo effect of dietary supplementation with a nutrient mixture containing lysine, proline, ascorbic acid and green tea extract (NM) on the development of urethane-induced lung tumors in male A/J mice.

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Inhibition of Malignant Mesothelioma Cell Matrix Metalloproteinase Production and Invasion by a Novel Nutrient mixture

M.W. Roomi, V. Ivanonv, T. Kalinovsky, A. Niedzwiecki, M. Rath
Experimental Lung Research 2006, 32(3&4): 69-79

Introduction:
Malignant mesothelioma (MM), an asbestos-associated cancer with no known cure, is a highly aggressive tumor causing profound morbidity and nearly universal mortality. Extracellular matrix (ECM) matrix metalloproteinases (MMPs) produced by tumor and stromal cells play a key role in tumor invasion and metastasis. Prevention of ECM degradation by MMP inhibition has been shown to be a promising therapeutic approach to inhibition of cancer development. A nutrient mixture (NM) containing lysine, proline, ascorbic acid and green tea extract, has shown significant anticancer activity against a number of cancer cell lines.

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