Head & Neck Cancers

M W Roomi, N W. Roomi, B Bhanap, A Niedzwiecki, M Rath

OJApo 2013; 2(4); 37-44

Abstract:

A majority of oral cancers is squamous cell carcinoma and tongue carcinomas comprise 30% of all oral cancers. Phytochemicals, herbal and dietary antioxidants have been reported to prevent cancers. A nutrient mixture containing, ascorbic acid, lysine, proline and green tea extract, among other nutrients, has previously been shown to exhibit a broad spectrum chemo preventative and therapeutic anti-cancer properties in a number of cell lines. In a recent study, we found that the nutrient mixture significantly inhibited acetaminophen induced hepatic and renal toxicity, and it suppressed carbon tetrachloride induced hepatic toxicity in ICR mice as well.

Roomi MW, Roomi N, Bhanap B, Niedzwiecki A, Rath M                                                    

Oncol Rep. 2013; 29(1):29-33

Abstract:

Retinoblastoma is one of the most common ocular malignancies in children under the age of six. Occasionally, retinoblastoma metastasizes to extraocular organs including the bone, lung and brain. Left untreated, retinoblastoma is fatal. At present, there is no effective treatment for metastatic retinoblastoma. We investigated the antineoplastic activity of a nutrient mixture (NM) (lysine, proline, ascorbic acid and green tea extract) at concentrations of 10, 50, 100, 500 and 1,000 µg/ml in triplicate at each dose in the human malignant retinoblastoma Y-79 cell line.

M. Waheed Roomi, Tatiana Kalinovsky, Matthias Rath, Aleksandra Niedzwiecki

Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050
ONCOLOGY REPORTS 37: 1907-1913, 2017

Abstract:

Brain tumors are highly aggressive, characterized by the secretion of high levels of matrix metalloproteinase (MMP)-2 and MMP-9 that degrade the extracellular matrix and basement membrane, allowing cancer cells to spread to distal organs. Various cytokines, mitogens, growth factors, inducers and inhibitors control MMP activity. We investigated the roles of these in the regulation of MMP-2 and MMP-9 in human glioblastoma T-98G cells.

M.W. Roomi, T. Kalinovsky, M. Rath, A. Niedzwiecki

Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050
Head and Neck Cancer, Avid Science 2017, pp 2-23

Head and neck squamous cell carcinoma (HNSCC), which develops in the mucous membranes of the oropharynx, nasopharynx, larynx and hypopharynx, can metastasize to other parts of the body, such as the lymph nodes or lungs leading to poor prognosis. Matrix metalloproteinases (MMPs), especially MMP-2 and -9, play critical roles in degradation of the extracellular matrix and their expression in head and neck carcinoma have been associated with progression and invasion of these tumors. In our studies we targeted various mechanisms of cancer by designing specific combinations of different polyphenols (PB) and combinations of polyphenols with vitamins and other micronutrients (NM).