Scientific Presentations


Natural Compounds Modulate Apolipoprotein E Gene and Protein Expression in Fibroblasts Derived from Young and Old Female Alzheimer’s Patients

G. Lopez, A. Goc, M. Rath, A. Niedzwiecki

American Journal of Food and Nutrition. 2024, 12(2), 49-58. DOI: 10.12691/ajfn-12-2-1

Alzheimer’s disease is the most common cause of dementia, accounting for approximately 60–80% of all dementia cases. Among the genetic risk factors identified, the apolipoprotein E (APOE) gene remains the strongest and most prevalent, impacting more than half of all Alzheimer’s disease cases. Targeting the APOE gene with nutrients and natural compounds could potentially benefit Alzheimer’s disease patients. In the search for such natural-derived compounds, we evaluated the effects of soy-derived estrogenic compounds such as genistein and daidzein, phospholipid precursors such as inositol and choline, phospholipid phosphatidylserine, and vitamins C and E as potent antioxidants on APOE gene transcription as well as APOE, APOE4, and Tau proteins expression in cells cultured in non-inflammatory and pro-inflammatory conditions.

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Cellular effects of fruit extracts and their active components applied individually and in combinations

M. Chatterjee, A. Goc, A. Niedzwiecki*, M. Rath

International Journal of Food Science and Nutrition, Vol 8, Issue 1, 2023, pp:76-81



Scope: Regular consumption of fruits and vegetables rich in vitamins, minerals and bioflavonoids is essential for general health. Since many people fail to meet those consumption targets, there is a huge industry marketing fruit juices, extracts and blends, all touting various health benefits. However, the efficacy of these blends is rarely reported or studied.

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Cellular effects of citrus compounds

M. Chatterjee, A. Goc, A. Niedzwiecki, M. Rath

International Journal of Food Science and Nutrition, December 2022



Scope: Consumption of fruits and vegetables has been inversely associated with morbidity and mortality from degenerative diseases. As different citrus compounds and fruit extracts provide a variety of physiological benefits and they are widely used in nutritional supplements and food products. However, there are no systematic studies comparing their efficacy at a cellular level.

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Micronutrients in mitigating the adverse health effects of air pollution – part 2

W. Sumera, M.Sc.

Journal of Cellular Medicine and Natural Health, July 2018



Air pollution is a major environmental risk to human health and well-being. According to WHO reports in 2012, ambient (outdoor) and indoor air pollution was linked to 7 million premature deaths worldwide. Most were attributed to cardiovascular diseases (stroke and ischemic heart disease), chronic obstructive pulmonary disease (COPD), lung cancer, and acute lower respiratory infections in children. Yet, 92% of the world population lives in places that exceed the WHO air quality guidelines. On the other hand, laboratory and clinical studies indicate that a nutritious diet and/or intake of micronutrients with antioxidant, anti-inflammatory, and detoxifying properties, may ameliorate many harmful health effects caused by polluted air.

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Nutritional Deficiencies in Young People: Causes, Consequences and Strategies

M. Chatterjee, A. Niedzwiecki

Journal of Cellular Medicine and Natural Health, April 2020



Being in the ‘prime of life’, health problems of individuals ranging from teenage years to late twenties rarely cause concern. However, this stage of life can be challenging for many reasons. As young men and women push their bodies to achieve athletic, aesthetic and professional goals, they may not keep track of nutrition, follow restrictive diets and develop undiagnosed nutritional deficiencies.

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