Blood Cancer

Antineoplastic effect of nutrient mixture on Raji and Jurkat T cells: the two highly aggressive non Hodgkin’s lymphoma cell lines

MW Roomi, BA Bhanap, NW Roomi, A. Niedzwiecki and M. Rath

Experimental Oncology 2009; 31(3): 149-155.

Abstract:

Non-Hodgkin lymphomas incidence has increased more than 70% in last 25 years. Aggressiveness, higher relapse rate, and treatment complications pose significant barriers. Decreased food intake and side effects of treatments make cancer patients vulnerable to deficiency of essential nutrients such as vitamin C, lysine, and proline leading to the formation of weak extra cellular matrix susceptible to easy breakdown by matrix metalloproteinase enzymes. Inhibition of these enzymes has shown promise in stopping metastasis.

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In vivo and in vitro antitumor effects of nutrient mixture in murine leukemia cell line P-388

Roomi MW, Roomi NW, Bhanap B, Rath M, Niedzwiecki A                                                        

ExpOncol. 2011; 33(2):71-7

Abstract:

Aim: Leukemia is characterized by uncontrolled marrow cell proliferation and metastatic foci. We investigated the antitumor potential of a nutrient mixture on malignant leukemia P-388 cells. Methods: The nutrient mixture containing lysine, proline, ascorbic acid, green tea extract and other nutrients is formulated to target key pathways in cancer progression.

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Nutrient Mixture Inhibits in vitro and in vivo Growth of Human Acute Promyelocytic Leukemia HL-60 Cells

MW Roomi, NW Roomi, B Bhanap, A Niedzwiecki, M Rath;                                                        

Exp Oncol. 2011;33(4):212-215

Abstract:

Aim:Untreated acute promyelocytic leukemia is the most malignant form of acute leukemias, with median survival of less than one month. We investigated in vitro and in vivo synergistic effects of a nutrient mixture (NM) containing ascorbic acid, lysine, proline, and green tea extract, on acute promyelocytic leukemia HL-60 cells.

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Repression of matrix metalloproteinases and inhibition of cell invasion by a nutrient mixture, containing ascorbic acid, lysine, proline, and green tea extract on human Fanconi anemia fibroblast cell lines

Roomi MW,Bhanap B, Roomi NW, Niedzwiecki A, Rath M.

ExpOncol. 2013; 35(1):20-24.

Abstract:

Aim: Fanconi Anemia, an autosomal recessive disorder, is characterized by chromosomal abnormality leading to birth defects, progressive bone marrow failure, and a high probability of developing malignancy at an early age. Head and neck squamous cell carcinoma and myeloid leukemia are the major causes of cancer related morbidity and mortality in Fanconi anemia patients.

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In vitro inhibition of matrix metalloproteinases, invasion and growth of Fanconi anemia human FANCA and FANCC lymphoblasts by nutrient mixture

Roomi MW,Bhanap B, Roomi NW, Niedzwiecki A, Rath M.

Exp Oncol.2014;36(3):212-4.

Abstract: 

Aim: Fanconi anemia is a rare genetic disorder with high propensity for development of cancers, such as aplastic anemia, leukemia and head and neck cancers. Collagen digesting matrix metalloproteinase (MMP) enzymes have been implicated in for their role in various malignancies and to promote metastasis.

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