Inhibitory Effects of Ascorbic Acid, Proline, and Lysine Supplementation on Matrigel Invasion by Human Breast Cancer Cells MDA-MB-231

Netke SP, Ivanov V, Roomi MW, Niedzwiecki A, Rath M.

Presented at: 
19th Annual Miami Breast Cancer Conference, Miami Beach, Florida, February 27–March 3, 2002.

Published in: 
Conference Proceedings.


The results from this study demonstrated that while an individual nutrient, such as ascorbic acid, can inhibit the invasion of cancer cells through Matrigel (a model for extracellular matrix), the synergistic effect of a combination of ascorbic acid, lysine, and proline significantly enhances the inhibition of invasion. This implies that this nutrient mixture is a promising candidate for therapeutic use in the treatment of breast cancer cells, by blocking metastasis.