Metastatic and Cytoxic Effects of Ascobigen and Iso-Ascorbigen in Human Cancer Cell Lines

M.W. Roomi, A. Bogale, V. Ivanov, S. Netke, A. Niedzwiecki and M. Rath

Presented at: 
American College of Nutrition, 43rd Annual Meeting, San Antonio, Texas, Oct. 3-6, 2002.

Published in: 
J. Am. Coll. Nut. 21: 54, 2002


Diets rich in cruciferous vegetables such as cabbage, broccoli and Brussel sprouts have been shown to prevent certain types of cancer. This discovery led to the isolation of ascorbigen (Ascorb) in cabbage as a major indole-containing compound—a structure fusing indole 3-carbinol (I3C) with ascorbic acid (AA). Iso-ascorbigen (iso-Ascorb) is a synthetic analogue in which AA is replaced by iso-ascorbic acid (iso-AA). Very little is known about the effect of these two compounds as antineoplastic agents.