Nutrient Synergy – A Specific Formulation of Nutrients Containing Lysine, Proline, Ascorbic Acid, and Epigallocatechin Gallate Inhibits Matrix Metalloproteinases Activity and Invasion Potential of Human Cancer Cell Lines

Roomi MW, Netke SP, Ivanov V, Niedzwiecki A, Rath M

Presented at: 
European Organization for Research and Treatment of Cancer (EORTC), AACR and NCI Symposium on Molecular Targets and Cancer Therapeutics, Frankfurt, Germany, Nov. 19-22, 2002.

Published in: 
European Journal of Cancer, 38 (Suppl. 7), p. S86, Abstract #280, 2002.


These results demonstrated that the synergistic effect of ascorbic acid, lysine, proline, and epigallocatechin gallate significantly inhibited the metastasis potential of human melanoma, breast and liver cancer cells by inhibiting the expression of MMPs and Matrigel invasion, suggesting this non-toxic agent as a promising candidate for the treatment of human cancers.