Anti-Tumorigenic Activity of Nutrient Synergy in Human Breast Cancer Lines MDA-MB-231 and MCF-7

Roomi MW, Ivanov V, Niedzwiecki A, Rath M

Presented at: 
The 8th Annual Multidisciplinary Symposium on Breast Disease, Amelia Island, FL, February 13-16, 2003.

Published in: 
The 8th Annual Multidisciplinary Symposium on Breast Disease Conference Proceedings, Abstract # A019.


Breast cancer, worldwide the most prevalent cancer and the second leading cause of cancer deaths in women today (after lung cancer), metastasizes by the enzymatic destruction of surrounding connective tissue to metastasize. This study demonstrated that the nutrient mixture of lysine, proline, ascorbic acid and epigallocatechin gallate exerted potent synergistic anti-metastatic effect on human breast MDA-MB-231 cancer cells by inhibiting MMP expression and Matrigel invasion. These results suggest that this nutrient formulation is a valuable and promising candidate for treating estrogen- insensitive breast cancer.