Inhibitory Effect of Nutrient Synergy, a Specific Formulation of Nutrients Containing Lysine, Proline, Ascorbic Acid, and Epigallocatechin Gallate, on Matrix Metalloproteinase Activity and Invasion of Human Fibrosarcoma HT-1080 Cells

Roomi MW, Ivanov V, Netke SP, Niedzwiecki A, Rath M

Presented at: 
FASEB (Federation of American Societies for Experimental Biology) Conference, San Diego, CA, April 11-15, 2003.

Published in: 
The FASEB Journal, 17 (Part II, #5) p. A1368, Abstract #867:1, March 2003.



To reproduce and spread to other parts in the body, cancer cells degrade the extracellular matrix (ECM) by secreting various matrix metalloproteinases (MMPs), which have been correlated with the aggressiveness of tumor growth. In this study, Nutrient Synergy, a specific mixture of nutrients, including lysine, proline, ascorbic acid, and epigallocatechin gallate, significantly inhibited the expression of both MMP-2 and MMP-9, and the invasion of human fibrosarcoma HT-1080 cells through Matrigel in a dose dependent fashion, without toxic effect to cells. These results suggest that Nutrient Synergy has great potential as a natural, non-toxic therapeutic regimen based on its anti-metastatic activity.