Chemoprevention with Chlorophyllin by Inhibiting MMP Expression and Invasiveness: In Vitro Studies

M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath

Presented at: 
XXV. International Congress of Physiological Sciences, March 31-April 5, 2005, San Diego

Published in: 
The FASEB Journal, Abstracts, Abstract #860.11


Fibrosarcoma is an aggressive and highly metastatic cancer with poor prognosis associated with both the aggressive metastatic spread characteristic of this cancer and the lack of efficacy in current treatment modalities to prevent, counteract or slow tumor progression. Chlorophyllin (CHL), a water-soluble derivative of chlorophyll, used as a food colorant and over-the counter medicine, exhibited potent antimetastatic activity on human fibrosarcoma HT180cells in vitro; it inhibited Matrigel invasion and MMP expression - both important parameters for cancer prevention.