Anti-Angiogenic and Antimetastatic Activities of a Novel Nutrient Formulation of Lysine, Proline, Ascorbic Acid, and Green Tea Extract

M.W. Roomi, V. Ivanov, A. Niedzwiecki and M. Rath
Matthias Rath Research, Cancer Research Division, 1260 Memorex Drive, Santa Clara, CA 95050

Presented at: 
96th Annual Meeting of the AACR, Anaheim, CA, April 16-20, 2005.

Published in: 
Proceedings of the 96th Annual Meeting of the AACR, Abstract #2991.


Angiogenesis, a process of abnormal new blood vessel development from pre-existing capillaries, is a main prerequisite for tumor growth. It is a complex multi-step process that plays an important role in tumor growth, invasion and metastasis. We designed a novel formulation (NM) of ascorbic acid, lysine, proline and green tea extract that has shown significant anti-cancer activity against a number of cancer cell lines. The aim of the present study was to determine whether NM exhibits anti-angiogenic and antimetastatic effects using in vitro and in vivo experimental models. Since angiogenesis depends on the interaction between tumor cells and endothelial cells, we sought to determine the effect of NM on both cell types.