Inhibition of Cell Invasion and MMP Production by a Nutrient Mixture in Malignant Liposarcoma Cell Line SW-872

M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath
Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050

Presented at: 
International Research Conference on Food, Nutrition, and Cancer, Washington, DC, July 14-15, 2005

Published in: 
Poster Abstract Book, Abstract # 36


Liposarcoma, a fat cell malignancy, commonly metastasizes (usually to lungs and liver). Overall 5-year survival rate of patients with deep high-grade liposarcoma is less than 50%. Extracellular matrix (ECM) matrix metalloproteinases (MMPs) produced by tumor and stromal cells play a key role in tumor invasion and metastasis. The nutrient mixture (NM) of lysine, proline, ascorbic acid and green tea extract significantly inhibited liposarcoma cell growth, MMP expression and invasion - important parameters for cancer prevention. These results are significant as they indicate that the nutrient mixture has therapeutic potential as a non-toxic treatment strategy for liposarcoma.