A Novel Nutrient Mixture as an Antileukemic Agent with Matrix Metalloproteinase and Invasion Inhibitory Activities

M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath
Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050

Presented at: 
2nd International Tumor Metabolism Summit, Genova, Italy, October 7-8, 2005

Published in: 
2nd International Tumor Metabolism Summit Proceedings


Acute myeloid leukemia (AML), the most common leukemia in adults, is characterized by uncontrolled proliferation of myeloid blasts or lymphoid cell lines. Although chemotherapy and supportive management have resulted in high remission rates, fewer than 50% of young patients and 10%-15% of patients over 60 years are cured of their disease. We found that the nutrient mixture (NM) of ascorbic acid, lysine, proline, and green tea extract demonstrated a potent synergistic anticancer effect by inhibiting human promyelocytic leukemia cell HL-60 proliferation, MMP activity, and invasion through Matrigel in vitro. Our results are significant as they indicate that this nutrient mixture is a promising non-toxic therapeutic agent for acute myeloid leukemia.