M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath
Dr. Rath Research Institute, Cancer Division, Santa Clara, CA 95050
International Society for Biological Therapy of Cancer, Nov 10-13, 2005, Alexandria, VA.
International Society for Biological Therapy of Cancer Proceedings, Abstract #96.
Leukemia, a disorder of bone marrow characterized by unrestrained white blood cell proliferation, results in formation of metastatic colonies and penetration through matrix barriers and blood vessel walls. Degradation and invasion through matrix barriers and vessel walls is mediated by secretion of MMPs. A nutrient mixture (NM) containing lysine, proline, ascorbic acid and green tea extract exhibited significant inhibition of Matrigel invasion (with total block at 1000 _g/ml) and significant antiproliferative effect at 500 _g/ml (70%) and 1000 _g/ml (90%). These results are important as they indicate NM is a promising therapeutic agent for leukemia.