M.W. Roomi, V. Ivanov, A. Niedzwiecki and M. Rath
Dr. Rath Research Institute, Oncology Division, 1260 Memorex Drive, Santa Clara, CA 95050
45th Annual Meeting of The American Society for Cell Biology, San Francisco, December 10-14, 2005
45th Annual Meeting of The American Society for Cell Biology, San Francisco, December 10-14, 2005 Proceedings, Abstract #L461
Five-year survival rates for brain tumors are among the lowest of all cancers (pancreatic and lung being the shortest). The median survival of patients with malignant glioma is 14-36 weeks, depending upon treatment regimens, mainly due to invasion into the surrounding brain. A unique non-toxic nutrient mixture (NM) consisting of lysine, proline, ascorbic acid and green tea extract, shown to exhibit anti-tumor effects in a number of cancer cell lines both in vitro and in vivo, significantly inhibited glioma cell MMP secretion and invasion in vitro, suggesting NM as a potentially effective treatment strategy to block cell invasion of gliomas.