M.W. Roomi, V. Ivanov, A. Niedzwiecki and M. Rath
Dr. Rath Research Institute, Oncology Division, 1260 Memorex Drive, Santa Clara, CA 95050

Presented at: 
45th Annual Meeting of The American Society for Cell Biology, San Francisco, December 10-14, 2005

Published in: 
45th Annual Meeting of The American Society for Cell Biology, San Francisco, December 10-14, 2005 Proceedings, Abstract #L461

Comment

Five-year survival rates for brain tumors are among the lowest of all cancers (pancreatic and lung being the shortest). The median survival of patients with malignant glioma is 14-36 weeks, depending upon treatment regimens, mainly due to invasion into the surrounding brain. A unique non-toxic nutrient mixture (NM) consisting of lysine, proline, ascorbic acid and green tea extract, shown to exhibit anti-tumor effects in a number of cancer cell lines both in vitro and in vivo, significantly inhibited glioma cell MMP secretion and invasion in vitro, suggesting NM as a potentially effective treatment strategy to block cell invasion of gliomas.