A Nutrient Mixture Attenuates Acetaminophen Hepatic and Renal Toxicity in ICR

M.W. Roomi, V. Ivanov, A. Niedzwiecki, M. Rath
Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050

Presented at: 

Society of Toxicology, San Diego, CA, March 5-9, 2006

Published in: 

The Toxicologists (suppl Toxicological Sciences) 90 (1), Abstract 1398, pg 285, 2006.


Overdosing with acetaminophen, a common over-the-counter analgesic, is often fatal, causing severe liver and kidney damage in humans and animals. We tested the protective effect of a nutrient supplemented diet (0.5% NM) in mice injected ip with acetaminophen (600 mg/kg) using a nutrient mixture that has previously demonstrated therapeutic and chemoprotective properties. The nutrient supplemented mice were protected against acetaminophen-induced liver and kidney damage, while the unsupplemented mice exhibited liver and kidney pathology and associated serum enzyme abnormality. Thus, the nutrient mixture provides protection against acetaminophen-induced hepatic and renal damage.