Anti-Atherogenic Effects of a Mixture of Ascorbic Acid, Lysine, Proline, Arginine, Cysteine and Green Tea Phenolics in Human Aortic Smooth Muscle Cells

Ivanov V, Ivanova S, Roomi MW Netke SP, Niedzwiecki A, Rath M.

Presented at: 
12th International Congress on Cardiovascular Pharmacotherapy, Barcelona, Spain, May 7-10, 2003.

Published in: 
The Abstract Book by Prous Science, 2003.



In this study, the synergistic anti-atherogenic effects of nutrients such as ascorbic acid, lysine, proline, arginine, cysteine, and epigallocatechin gallate (from green tea extract) were investigated in cultured human aortic smooth muscle cell (SMC) by measuring SMC growth rate, invasiveness, matrix metalloproteinase-2 (MMP-2) expression, and secretion of monocyte chemoattractant protein-1 (MCP-1) and interleukin-6 (IL-6). By inhibiting the atherogenic response of vascular smooth muscle cells to pathological stimuli, Nutrient Synergy blocks the development of atherosclerotic lesions.