Mixture of Natural Nutrients Reduces Collagen Matrix Contraction Driven by Aortic Smooth Muscle Cells

V. Ivanov, S. Ivanova, M.W. Roomi, A. Niedzwiecki, M. Rath
Matthias Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050

Presented at: 

International Academy of Cardiology, 12th World Heart Congress, New Trends in Research, Diagnosis, and Treatment Vancouver, B.C., Canada, July 16-19, 2005

Published in: 

The Journal of Heart Disease; vol 4(1): 99, Abstract #394


Impaired arterial smooth muscle contractility plays a leading role in the development of systemic hypertension. Structural changes, such as occlusive atherosclerotic plaque formation, and functional changes, such as hormonal disturbances, play roles in pathophysiological mechanisms of altered arterial contractility. Accelerated gel contraction was accompanied by elevated secretion of MMPs into cell culture media. We found that purified polyphenols and catechins counteracted SMC-dependent collagen gel contraction; this gel relaxation effect was further enhanced by addition of ascorbic acid and amino acids lysine, arginine, cysteine and proline to green tea extract. A reduction in gel contraction correlated with decreased MMP expression. These results are significant as they indicated that nutrients can effectively counteract angiotensin-mediated excessive stimulation of arterial tissue contraction and have therapeutic potential in hypertension.