Nutrient Synergy - an Important Inhibitor of MMP-2 Expression and Invasion by Human Ovarian Cancer Cell Line SK-OV-3

M.W. Roomi, V. Ivanov, A. Niedzwiecki and M. Rath
Matthias Rath Research., Cancer Research Division, Santa Clara, CA 95050

Presented at: 
International Society for Biological Therapy of Cancer, San Francisco, November 4-7, 2004.

Published in: 
Journal of Immunotherapy (Official journal of International Society for Biological Therapy of Cancer) volume 27, number 6, page S8, November/December 2004.


Due to high metastasis rates, ovarian cancer is the deadliest of the gynecologic cancers and the fifth leading cause of cancer death among U.S. women. We studied the synergistic effect of a unique nutrient formulation containing lysine, proline, arginine, ascorbic acid, and epigallocatechin gallate on metastatic parameters on human ovarian cancer cells SK-OV-3, such as effect on MMP-2 and –9 expression and cancer cell invasive potential. Our results demonstrated complete inhibition of MMP-2 expression at 50 mg/ml and of Matrigel invasion at 1000 mg/ml. These findings are significant as they suggest that nutrient synergy would be an effective and safe therapeutic regimen for treatment of ovarian cancer.