Inhibition of Malignant Mesothelioma Cell Matrix Metalloproteinase Production and Invasion by a Novel Nutrient Supplement

M.W. Roomi, V. Ivanov, A. Niedzwiecki and M.Rath
Matthias Rath Research Institute, Cancer Division, Santa Clara, CA

Presented at: 
Directions and Needs in Asbestos Research, University of Montana, July 28-29, 2005

Published in: 
Conference proceedings



Malignant mesothelioma (MM) is an asbestos-associated cancer with no known cure. It is a highly aggressive tumor causing profound morbidity and nearly universal mortality. Extracellular matrix (ECM) matrix metalloproteinases (MMPs) produced by tumor and stromal cells play a key role in tumor invasion and metastasis. The nutrient mixture (NS) of ascorbic acid, lysine, proline, arginine and green tea extract significantly inhibited MM cell MMP expression and invasion- both important parameters for cancer prevention, suggesting this nutrient mixture has strong therapeutic potential for treatment of malignant mesothelioma.