Nutrient Mixture Prevents Hyper-Reactive Response of Bronchial Muscle to Inflammatory and Allergic Stimuli

Ivanov V, Roomi MW, Niedzwiecki A, Rath M
Matthias Rath Research Institute BV, Santa Clara, CA.

Presented at: 

46th Annual Meeting of the American College of Nutrition, Charleston, South Carolina, Sept 22-25, 2005.

Published in: 

Journal of the American College of Nutrition, vol 24(5), Oct 2005, abstract #74


Asthma, a chronic pathological condition manifested by bronchial hyper-reactivity and bronchial spasm is poorly managed by conventional treatment. Pathogenesis is linked to infection, inflammation, and allergic reaction to pollution. We found that a nutrient mixture of ascorbic acid, amino acids lysine, proline, arginine and cysteine, and polyphenols from green tea extract significantly inhibited the hyper-reactive response of bronchial smooth muscle cells in vitro to histamine and to inflammatory mediators, such as bacterial lipopolysaccharides and endothelin-1. Furthermore, the relaxation effect of the nutrient mixture was greater than the combined effect of its individual components. These findings are significant as they indicate that nutrient synergy has therapeutic potential in safely and effectively controlling asthma.