Lyme Disease

Inhibition of Borrelia Burgdorferi-Induced TLR2-NFκB Canonical Signaling by Gallic Acid through Targeting the CD14+ Adaptor Protein and p65 Molecule

Goc A, Rath M, Niedzwiecki A.

International Journal of Molecular Science 2022, 23, 10987.

Abstract: The cases of Lyme disease caused by Borrelia burgdorferi infection have been increasing throughout Northern America and Europe. This pathogen, if not treated in a timely manner with antibiotics, can cause persisting and debilitating health outcomes. In the search for novel agents against B. burgdorferi, we investigated a phenolic compound—gallic acid—for its anti-Borrelia and anti-inflammatory effects.

Specific composition of polyphenolic compounds with fatty acids as an approach in helping to reduce spirochete burden in Lyme disease: in vivo and human observational study

Anna Goc, Gebhard Gehring, Hartmut Baltin, Aleksandra Niedzwiecki and Matthias Rath

Abstract: Background: Lyme disease (LD) is a tick-borne infection caused by Borrelia burgdorferi sensu lato. The current therapeutic approach to this disease is limited to antibiotics. However, after their administration, about 20% of patients experience delayed onset of this illness manifesting as lingering persistent symptoms.

Anti-borreliae efficacy of selected organic oils and fatty acids

A. Goc, A. Niedzwiecki, M. Rath

Abstract: Background: Borrelia sp., is a causative pathogen of Lyme disease which has become a worldwide health concern. Non-toxic approaches especially directed toward latent persistent forms of this pathogen are desired. Lipids in the form of volatile and non-volatile oils, and fatty acids with proven anti-borreliae efficacy could become an additional support or an alternative for consideration in treatment approaches.

Synergistic Anti-Borreliae Efficacy of a Composition of Naturally-occurring Compounds: an In vitro Study

A. Goc , A. Niedzwiecki, M. Rath

J Nutri Bio, 5(1): 350-363 (2019)

Abstract: Background: Borrelia sp., which is a pathogenic agent of Lyme diseases in mammals, has become an increasing problem worldwide due to the emergence of persistence. In this study we investigated whether a defined composition of naturally occurring substances could display a broad and synergistic action in vitro against both active and persistent forms of Borrelia spp.

Reciprocal cooperation of phytochemicals and micronutrients against typical and atypical forms of Borrelia spp.

Anna Goc, Aleksandra Niedzwiecki, Matthias Rath

Journal of Applied Microbiology 2017, 123(3): 637-650

Abstract: Aims: Borrelia spp., a causative pathogenic factor of Lyme disease, has become a major public health threat. Current treatments based on antibiotics often lead to relapse after their withdrawal. Naturally derived substances that could work synergistically to display higher efficacy compared to the individual components may serve as a resource for the development of novel approaches to combat both active and latent forms of Borrelia spp.