Cellular effects of fruit extracts and their active components applied individually and in combinations

M. Chatterjee, A. Goc, A. Niedzwiecki*, M. Rath

International Journal of Food Science and Nutrition, Vol 8, Issue 1, 2023, pp:76-81



Scope: Regular consumption of fruits and vegetables rich in vitamins, minerals and bioflavonoids is essential for general health. Since many people fail to meet those consumption targets, there is a huge industry marketing fruit juices, extracts and blends, all touting various health benefits. However, the efficacy of these blends is rarely reported or studied.

Cellular effects of citrus compounds

M. Chatterjee, A. Goc, A. Niedzwiecki, M. Rath

International Journal of Food Science and Nutrition, December 2022



Scope: Consumption of fruits and vegetables has been inversely associated with morbidity and mortality from degenerative diseases. As different citrus compounds and fruit extracts provide a variety of physiological benefits and they are widely used in nutritional supplements and food products. However, there are no systematic studies comparing their efficacy at a cellular level.

Micronutrients in mitigating the adverse health effects of air pollution – part 2

W. Sumera, M.Sc.

Journal of Cellular Medicine and Natural Health, July 2018



Air pollution is a major environmental risk to human health and well-being. According to WHO reports in 2012, ambient (outdoor) and indoor air pollution was linked to 7 million premature deaths worldwide. Most were attributed to cardiovascular diseases (stroke and ischemic heart disease), chronic obstructive pulmonary disease (COPD), lung cancer, and acute lower respiratory infections in children. Yet, 92% of the world population lives in places that exceed the WHO air quality guidelines. On the other hand, laboratory and clinical studies indicate that a nutritious diet and/or intake of micronutrients with antioxidant, anti-inflammatory, and detoxifying properties, may ameliorate many harmful health effects caused by polluted air.

Nutritional Deficiencies in Young People: Causes, Consequences and Strategies

M. Chatterjee, A. Niedzwiecki

Journal of Cellular Medicine and Natural Health, April 2020



Being in the ‘prime of life’, health problems of individuals ranging from teenage years to late twenties rarely cause concern. However, this stage of life can be challenging for many reasons. As young men and women push their bodies to achieve athletic, aesthetic and professional goals, they may not keep track of nutrition, follow restrictive diets and develop undiagnosed nutritional deficiencies.

Seaweed – a substitute for ascorbic acid

V. Ivanov, S. Ivanova, A. Niedzwiecki, M. Rath

Journal of Cellular Medicine and Natural Health, June 2016



Objective: Seaweeds are an abundant and readily available source of both bulk nutrients and biologically active nutrients. We hypothesized that seaweed polysaccharide fucoidan could serve as a temporary substitute for ascorbic acid under conditions of vitamin C deficiency by beneficially affecting structural properties of the arterial wall.Methods: This was tested in an experimental model of cultured smooth muscle cells (AoSMC) and endothelial cells (AoEC) isolated from human aorta and cultured dermal fibroblasts (DFB) isolated from human skin. The effects of fucoidan in cultured cells were characterized by immunochemical assessment of deposition of selected extracellular matrix (ECM) proteins and glycosaminoglycans. Results: Physiological concentrations of fucoidan effectively stimulated ECM deposition of proteins, presented by collagen types I and IV, and glycosaminoglycans, presented by heparan sulfate and hyaluronic acid, by AoSMC and DFB in manner and extent comparable to corresponding actions of ascorbic acid. Activity of a combination of two nutrients did not exceed activity of the compounds applied individually. Neither fucoidan nor ascorbic acid modulated ECM components deposition by AoEC under used experimental conditions. Structural characteristics of ECM components deposited by cultured cells under influence of fucoidan remain a subject of future research. Conclusion: The results support our initial hypothesis on a capacity of seaweed sulfated polysaccharide fucoidan to possess vitamin C-like activity on ECM components production and deposition by arterial wall resident cells.