Essential nutrients suppress inflammation by modulating key inflammatory gene expression

V. Ivanov, J. Cha, S. Ivanova, T. Kalinofsky, M.W. Roomi, M. Rath, A. Niedzwiecki
International Journal of Molecular Medicine 2008; 22(6): 731-741

We investigated the effects of a nutrient mixture (NM) including ascorbic acid, quercetin, naringenin, hesperetin, tea catechins, lysine, proline, arginine and N-acetyl cysteine in experimental in-vivo and in-vitro inflammation triggered by bacterial lipopolysaccharide (LPS). BALB/c mice (n=36) were supplemented with NM (200 mg/kg BW) or ibuprofen (20 mg/kg BW) for two weeks. Blood plasma, collected three hours after a single intraperitoneal injection with LPS (1 mg/kg BW), was analyzed with 14 cytokine microarray.