Kidney and Bladder Cancer

Programmed Cell Death in Renal Cancer Cell 786-0 by a Novel Nutrient Mixture by Down Regulating u-PA, MMPs, and Up Regulating TIMPs

Roomi MW, Bhanap B, Niedzwiecki A, Rath M

Apoptosis (Open Access e-book) ISBN: 978-93-86337-72-6; Publisher: Avid Science In Press: 2018  (


Renal cell carcinoma (RCC) is highly erratic and unpredictable even when diagnosed at an early stage. The incidence of RCC is higher among African Americans than among Caucasians. The male to female ratio is 2:1. Except for blood in the urine, other symptoms such as abdominal, back or flank pain, weight loss, and abnormal blood counts, are vague signs and symptoms that delay the diagnosis.

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Anticancer Effect of Lysine, Proline, Arginine, Ascorbic Acid and Green Tea Extract on Human Renal Adenocarcinoma Line 786-0

M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
Oncology Reports 2006; 16(5): 943-947.

Five-year survival is limited to 60% in renal cancer patients at diagnosis. Due to the cancer’s resistance to conventional treatments and associated high morbidity, we investigated the antimetastatic effects of a specific nutrient mixture (NM) containing lysine, proline, arginine, ascorbic acid, and green tea extract on human renal adenocarcinoma cell line 786-0 by measuring: cell proliferation, modulation of MMP-2 and –9 secretion, and cancer cell invasive potential.

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Modulation of Human Renal Cell Carcinoma 786-0 MMP-2 and MMP-9 Activity by Inhibitors and Inducers in Vitro

M.W. Roomi, N. Roomi, V. Ivanov,T. Kalinovsky, A. Niedzwiecki, M. Rath
Medical Oncology 2006, 23(2): 245-250

A hallmark of renal cell carcinoma RCC) invasion is its ability to degrade ECM by local production of gelatinase enzymes. Although many studies on RCC have demonstrated the importance of MMPs, very little information is currently known regarding the effect of inducers and inhibitors. We therefore investigated the effect of inducers and inhibitors on RCC 786-0 in vitro.

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Anti-Tumor Effect of Ascorbic Acid, Lysine, Proline, Arginine, and Green Tea Extract on Bladder Cancer Cell Line T-24

M.W. Roomi, V. Ivanonv, T. Kalinovsky, A. Niedzwiecki, M. Rath
International Journal of Urology 2006, 13(4): 415-419.

Bladder cancer, the fourth incident cancer in men and tenth in women, is associated with a high rate of recurrence, even when treated in situ, and prognosis is poor once the cancer metastasizes to distant sites. Based on anticancer properties, we investigated the effect of a mixture of lysine, proline, arginine, ascorbic acid, and green tea extract on human bladder cancer cells T-24 by measuring: proliferation, MMP expression, and cancer cell invasive potential.

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Pleiotropic Effects of a Micronutrient Mixture on Critical Parameters of Bladder Cancer in Bladder Cancer, Etymology, Diagnosis and Treatment

M.W. Roomi, T. Kalinovsky, A. Niedzwiecki and M. Rath
Bladder Cancer: Etymology, Diagnosis and Treatments, ed. W.E. Nilsson, Nova Science Publishers, Inc, 2010, Ch. 12, pp. 229-243

Consumption of a plant-based diet has been associated with prevention of the development and progression of cancer. We have developed strategies to inhibit cancer by increasing the stability and integrity of connective tissue as the common mechanisms used by all types of cancer cells for their development and spread. This can be achieved naturally through the synergistic effects of selected nutrients, such as lysine, proline, ascorbic acid and green tea extract (NM).

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