Influenza

Holistic efficacy of specific nutrient synergy against avian flu virus: pathology and immunomodulation

E.K. Barbour, E.G. Rayya, H.A. Shaib, R.G. El Hakim, A.M. Abdel Nour, A.Niedzwiecki, S. Harakeh, M. Rath
Veterinaria Italiana 2007, 43(1): 43-54

Summary:
The authors evaluated the holistic efficacy of nine specific nutrient synergy (NS) against avian influenza virus (AIV) strain Lebanon 1 (H9N2). The study included two segments; the first was designed to determine the minimum dose among four doses (1X, 2X, 3X and 4X in which X = 24.4 mg/ml/bird) of NS, administered intraoesophageally, once per day between 7 and 14 days of age, resulting in an improvement of chicken performance without any toxic side-effects; the second aimed at reducing pathological effects and inducing immunomodulation by the determined safe dose of NS in chickens exposed to AIV.

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Allevation of histopathological effects of avian influenza virus by a specific nutrient synergy

Babour EK, Rayya EG, Shaib H, El Hakim RG, Niedzwiekci A, Abdel Nour AM, Harakeh S, Rath MIntern 
The International Journal of Applied Research in Veterinary Medicine 2007; 5(1): 9-16

Abstract:
This study focused on the effects of a nutrient mixture containing ascorbic acid, lysine, proline, green tea extract and other micronutrients in alleviating the histopathologic effects of avian influenza virus.

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Suppression of influenza A virus nuclear antigen production and neuraminidase activity by a nutrient mixture containing ascorbic acid, green tea extract and amino acids

R. Jariwalla, M.W. Roomi, B. Gangapurkar, T. Kalinovsky, A. Niedzwiecki, M. Rath
Biofactors 2007, 31(1): 1-15

Abstract:
Influenza, one of the oldest and most common infections, poses a serious health problem causing significant morbidity and mortality, and imposing substantial economic costs. The efficacy of current drugs is limited and improved therapies are needed. A unique nutrient mixture (NM), containing ascorbic acid, green tea extract, lysine, proline, N-acetyl cysteine, selenium among other micronutrients, has been shown to exert anti-carcinogenic and anti-atherogenic activity both in vitro and in vivo. Many of the constituents of NM have been shown to have an inhibitory effect on replication of influenza virus and HIV.

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Effects of a nutrient mixture on infectious properties of the highly pathogenic strain of avian influenza virus A/H5N1

P.G. Deryabin, D.K. Lvov, A.G. Botikov, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath 
Biofactors 2008, 33(2): 85-97

Abstract:
Numerous outbreaks of avian influenza virus infection (A/H5N1) have occurred recently, infecting domestic birds, chicken and ducks. The possibility of the emergence of a new strain of influenza virus capable of causing a pandemic in humans is high and no vaccine effective against such a strain currently exists. A unique nutrient mixture (NM), containing lysine, proline, ascorbic acid, green tea extract, N-acetyl cysteine, selenium among other micro nutrients, has been shown to exert a wide range of biochemical and pharmacological effects, including an inhibitory effect on replication of influenza virus and HIV.

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Inhibition of cellular invasive parameters in influenza A virus-infected MDCK and Vero cells by a nutrient mixture

M.W. Roomi, R.J. Jariwalla, T. Kalinovsky, N. Roomi, A. Niedzwiecki, M. Rath
BioFactors 2008; 33: 61-75

Influenza, a long-standing common infection, poses a serious health problem causing significant morbidity and mortality, and imposing substantial economic costs. To date there are no effective antiviral therapies. A unique nutrient mixture (NM), containing lysine, proline, ascorbic acid, green tea extract, N-acetyl cysteine and selenium among other micro nutrients, has been shown to exert a wide range of biochemical and pharmacological effects, among them anti-carcinogenic and anti-atherogenic activity both in vitro and in vivo.

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Micronutrients and Nutrient Synergy in Immunodeficiency and Infectious Disease

 

Jariwalla RJ, Niedzwiecki A, Rath M
Botanical Medicine in Clinical Practice, eds. Preedy VR and Watson RR., Chapter 23, 2008

Abstract:
Good nutrition is vital to immune function and disease resistance. Conversely poor nutritional status or malnutrition can lower immunity and predispose to infection. Nutritional deficiencies are common in disorders of the immune system and in viral and bacterial infections. Experimental studies conducted to date with micronutrients have revealed beneficial effects with the potential to combat both immunodeficiency disease and microbial infection.

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Micronutrients in the global fight against influenza

Jariwalla RJ, Roomi MW, Kalinovsky T, Rath M, Niedzwiecki A
In: Global View of the Fight Against Influenza, edited by Petar Mitrasinovic, Nova Publishers, 2009

Abstract:
Influenza remains a major health threat among infectious diseases, affecting a fifth of the world’s population. Current vaccines and drugs have limited efficacy and there is an urgent need for effective therapies. Influenza virus A not only infects susceptible (alveolar) cells in the lungs, but also manifests in extrapulmonary areas, which require basement membrane disruption by matrix metalloproteinases (MMPs) capable of degrading collagen type IV.

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