A significant association has been reported between tumor aggression and increased levels of MMP-2 and MMP-9. Therefore, MMPs are used as diagnostic and prognostic biomarkers in many clinical trials and experimental studies. MMP inhibitors (MMPIs) seem to be the logical targets for the therapeutic intervention in cancer. The rationale for developing MMPIs for halting cancer has been around for more than three decades. However, the clinical trials of synthetic MMPIs have not produced favorable results. In this review, we summarize the results of our in vitro studies evaluating effects of a natural and non-toxic nutrient mixture on inhibition of the cancer biomarkers; MMP-2 and MMP-9 in the treatment and control of metastasis of 42 different cancer cell lines from 13 representative classes of malignancies.
Keywords: MMP-2; MMP-9; Cancer biomarkers; Metastasis