M. W. Roomi, A. Niedzwiecki, M. Rath

Journal of Cellular Medicine and Natural Health, July 2019

Abstract:

Chemotherapy and radiation are basic cancer therapies aimed at reducing tumor burden. These toxic agents destroy both malignant and normal cells thereby increasing the population of dying cells and/or tumor debris and causing other changes in the tumor microenvironment. These dead cells can act as a source of stimulants on surviving tumor cells leading to recurrence of tumors, thereby reducing survival rates. We investigated the effects of docetaxel-induced debris of 4T1 cells—a murine breast cancer line—on breast tumor growth in female mice. Female athymic mice were divided into three groups.

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