Nutritional Improvement of Metabolic Syndrome Parameters in Immature Fructose Fed Wild Type Mice

J.C. Cha, V. Ivanov, M.W. Roomi, T. Kalinovsky, A. Niedzwiecki, M. Rath
Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050
Molecular Medicine Reports, 2011, DOI: 10.3892/mmr.2011.562

Incidence of type 2 diabetes mellitus is increasing worldwide with both environmental and genetic factors implicated in its development.   Diabetes is often preceded by metabolic syndrome (MS) and can develop in normal adults ingesting a high fructose diet.  The effect of high fructose intake in development of MS in children and adolescents is less clear. 

Our objective was to study the effects of a nutrient mixture and metformin, a widely used oral diabetic medication, in modulating the physiological and biochemical parameters of a high fructose diet in immature mice.  C57BL/6J wild type mice of 7 weeks age were given 12% fructose in their water and were given either metformin in distilled water (MET) or a diabetic nutrient mix (DNM) over 7 weeks.  DNM-fed mice showed a decrease in systolic blood pressure, total cholesterol and fructosamine relative to the fructose-fed only group (p<0.05).  A discordant result was observed in the MET group, with a decrease in blood pressure but increases in total cholesterol and fructosamine (p<0.05).  Serum glucose did not change significantly among all groups.  Thus, symptoms of fructose-induced MS in young mice can be countered nutritionally. Additionally, metformin can improve some biochemical markers while worsening others.

Key Words: 
diabetes nutrient mix, metformin, C57/BL6J wild-type mice, fructose diet, metabolic syndrome parameters, fructosamine, lipid profile, systolic blood pressure

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