Natural Compounds Modulate Apolipoprotein E Gene and Protein Expression in Fibroblasts Derived from Young and Old Female Alzheimer’s Patients
G. Lopez, A. Goc, M. Rath, A. Niedzwiecki
American Journal of Food and Nutrition. 2024, 12(2), 49-58. DOI: 10.12691/ajfn-12-2-1
Abstract:
Alzheimer’s disease is the most common cause of dementia, accounting for approximately 60–80% of all dementia cases. Among the genetic risk factors identified, the apolipoprotein E (APOE) gene remains the strongest and most prevalent, impacting more than half of all Alzheimer’s disease cases. Targeting the APOE gene with nutrients and natural compounds could potentially benefit Alzheimer’s disease patients. In the search for such natural-derived compounds, we evaluated the effects of soy-derived estrogenic compounds such as genistein and daidzein, phospholipid precursors such as inositol and choline, phospholipid phosphatidylserine, and vitamins C and E as potent antioxidants on APOE gene transcription as well as APOE, APOE4, and Tau proteins expression in cells cultured in non-inflammatory and pro-inflammatory conditions.