W. Sumera, A. Niedzwiecki
Journal of Cellular Medicine and Natural Health, Jun 22, 2023
For centuries various plants and their natural compounds were used as antimicrobial agents. Most research work in this field has been done with individual compounds and directed towards their mechanisms of action or clinical applications.
The interest in natural anti-microbial approaches has intensified in recent years as extensive use of antibiotics, drugs and food antimicrobials have led to the occurrence of resistant microbial strains. Our research aims at increasing efficacy of natural compounds through their specific combinations, that allow for simultaneously affecting cellular mechanisms of interest and increasing efficacy at lower doses than individual compounds. Here we present results of the study that revealed that combination of vitamin C and L-lysine, which individually do not show such efficacy, have bacteriostatic and bactericidal effect against two Gram-negative strains Acinetobacter baumannii and Escherichia coli.