V. Ivanov, J. Cha, S. Ivanova, T. Kalinovsky, M. Rath, A. Niedzwiecki
Molecular Medicine Reports 3:417-425, 2010

Abstract:
We studied the effect of nutrient / herbal extract mixture (NM) supplementation prior to angiotensin II (AngII) administration on ApoE KO mice. AngII-mediated injuries, which included increased atherosclerotic lesion size (by 31%) and severity (by 200%) as well as increased number of necrotic cores (by 44%), were attenuated by NM supplementation, resulting in reduced lesion size by 20% (p=0.09), severity of lesion by 31% (p=0.13), and average number of necrotic cores per arterial tree by 39% (p=0.35) compared to mice fed the regular diet.

Read more: Nutrient supplementation modulates angiotensin II-mediated atherosclerosis in ApoE KO mice

J. Cha, V. Ivanov, S. Ivanova, T. Kalinovsky, M. Rath, A. Niedzwiecki

Molecular Medicine Reports, 2010, 3:565-570

Abstract
The dysregulation of renin-angiotensin system signaling is a contributing factor to the development of atherosclerosis and cardiovascular disease. We studied a progression of angiotensin II (AngII)-induced arterial wall atherosclerosis after its induction. Atherosclerosis was accelerated in ApoE (-/-) C57B6 mice by 4 weeks of continuous osmotic pump administration of AngII at 23 nmol/24 h. Changes in aortae were evaluated at 4 and 16 weeks after pump installation, as well as in mice without AngII administration. AngII supplementation induced additional lesions in the aortic arch and its vessels 4 weeks after pump installation showing that AngII had taken effect in comparison to non-AngII controls.…

Read more: Evolution of angiotensin II-mediated atherosclerosis in ApoE KO mice