Micronutrient Cooperation in Suppression of HIV Production in Chronically and Latently Infected Cells

Under the same assay conditions, the nucleoside analogue AZT did not significantly suppress HIV production at low to moderate concentrations (0.5 – 1.0 μg/ml) but reduced RT to 40% of control (p=0.02) at the highest dose tested (2 μg/ml). In both unstimulated and latently infected cells stimulated with mitogen (PMA or TNF-alpha), a nutrient mixture containing GT, AA and amino acids, gave significantly greater RT suppression than equivalent concentrations of key individual components. Nutrient effects on RT suppression were virus specific and not due to non-specific cellular toxicity. These results suggest that relatively nontoxic micronutrient combinations are more potent than single nutrients in suppressing virus production in chronically infected T cells, indicating cooperative effects of constituent nutrients in HIV inhibition.

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