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81. Programmed Cell Death in Renal Cancer Cell 786-0 by a Novel Nutrient Mixture by Down Regulating u-PA, MMPs, and Up Regulating TIMPs
(Kidney and Bladder Cancer)
... cell carcinoma (RCC) is highly erratic and unpredictable even when diagnosed at an early stage. The incidence of RCC is higher among African Americans than among Caucasians. The male to female ratio is ...
Created on 05 February 2018
82. Inhibition of proliferation and induction of apoptosis by a novel phytobiological mixture against breast cancer cell lines
(Scientific Presentations: Cancer)
... effects of a novel phytobiological mixture (PB)against two breast cancer cell lines :MDA-MB-231 and MCF-7.The PB mixture is composed of the following: quercetin, resveratrol, cruciferex, epigallocatechin-3-gallate ...
Created on 06 December 2017
83. Modulation of MMP-2 and -9 Secretion by Cytokines, Inducers and Inhibitors in Human Melanoma A-2058 Cells
(Skin Cancer)
... metalloproteinase (MMP)-2 and -9 secretions that degrade the extracellular matrix and basement membrane, allowing cancer cells to spread to distal organs.   Various cytokines, mitogens, growth factors, ...
Created on 26 April 2017
84. Modulation of MMP-2 and MMP-9 secretion by cytokines, inducers and inhibitors in human glioblastoma T-98G cells
(Head & Neck Cancers)
... tumors are highly aggressive, characterized by the secretion of high levels of matrix metalloproteinase (MMP)-2 and MMP-9 that degrade the extracellular matrix and basement membrane, allowing cancer cells ...
Created on 28 March 2017
85. In Vitro Modulation of MMP-2 and MMP-9 Secretion by Cytokines, Inducers, and Inhibitors in Head and Neck Squamous Carcinoma Cells (FaDu) and Tongue Carcinoma Cells (SCC-25)
(Head & Neck Cancers)
M W Roomi, B Bhanap, A Niedzwiecki and M Rath J Otolaryngol Rhinol 2017, 3:029; Vol 3 | Issue 1 Abstract: Head and neck squamous cell carcinoma (HNSCC) is a devastating disease with poor prognosis. ...
Created on 06 February 2017
86. Effects of Ascorbic Acid on Tax, NF-κB and MMP-9 in Human T-cell Lymphotropic Virus Type 1 Positive Malignant T-Lymphocytes
(Blood Cancer)
... Anti-Cancer Agents in Medicinal Chemistry, 2017, 17, 000-000 DOI: 10.2174/1871520617666170725160628 Abstract:  HTLV-1 is a retrovirus that infects CD4-positive cells and leads to Adult T-cell leukemia ...
Created on 05 January 2017
87. Antiproliferative Effects of Antioxidants Using HTLV-1 Positive and Negative Malignant T-Cells
(Scientific Presentations: Infectious Diseases)
...  Published in: American Society for Microbiology Final Program, p 143, Abstract #T-021. Comment Adult T-cell leukemia (ATL) is an aggressive malignancy caused by HTLV-1, for which currently there ...
Created on 17 April 2016
88. A Nutrient Mixture Modulates Ovarian ES-2 Cancer Progression By Inhibiting Xenograft Tumor Growth And Cellular Mmp Secretion, Migration And Invasion
(Scientific Presentations: Cancer)
... acid, lysine, proline, quercetin and green tea extract in vivo and in vitro on human ovarian cancer ES-2 cell line. In vivo, athymic female nude mice (n=12) were inoculated with 3x106 ES-2 cells subcutaneously ...
Created on 17 April 2016
89. Apoptosis of Human Fibrosarcoma Cells HT-1080 Triggered by a Novel Nutrient Mixture via Induction of Caspases
(Sarcomas)
... in athymic mice. Based on the observation, we investigated whether this phenomenon and the anti-cancer effects were due to the induction of apoptosis. Human fibrosarcoma cells HT-1080 were cultured in ...
Created on 09 March 2016
90. In Vivo and In Vitro Antitumor Effect of Ascorbic Acid, Lysine, Proline, Arginine and Green Tea Extract on Human Fibrosarcoma Cells HT-1080
(Sarcomas)
... in vitro on human fibrosarcoma cells HT-1080 by measuring: cell proliferation, modulation of MMP-2 and MMP-9, and invasive potential.   Methods: In vivo, we studied the growth of human fibrosarcoma ...
Created on 20 April 2015
91. Modulation Of Upa, Mmps And Their Inhibitors By A Novel Nutrient Mixture In Human Colorectal, Pancreatic And Hepatic Carcinoma Cell Lines
(Gastrointestinal Cancers)
... pancreatic and hepatic carcinomas are characterized by high levels of matrix metalloproteinase (MMP)-2 and -9 secretions that degrade the ECM and basement membrane, allowing cancer cells to spread to distal ...
Created on 15 April 2015
92. Modulation of Human Renal Cell Carcinoma 786-0 MMP-2 and MMP-9 Activity by Inhibitors and Inducers in Vitro
(Kidney and Bladder Cancer)
M.W. Roomi, N. Roomi, V. Ivanov,T. Kalinovsky, A. Niedzwiecki, M. Rath Medical Oncology 2006, 23(2): 245-250 Introduction: A hallmark of renal cell carcinoma RCC) invasion is its ability to degrade ECM ...
Created on 14 April 2015
93. Anti-Tumor Effect of Ascorbic Acid, Lysine, Proline, Arginine, and Green Tea Extract on Bladder Cancer Cell Line T-24
(Kidney and Bladder Cancer)
... lysine, proline, arginine, ascorbic acid, and green tea extract on human bladder cancer cells T-24 by measuring: proliferation, MMP expression, and cancer cell invasive potential. Methods: Human bladder ...
Created on 14 April 2015
94. Effect of a nutrient mixture on the localization of extracellular matrix proteins in HeLa human cervical cancer xenografts in female nude mice
(Female Reproductive Cancer)
...  Colorectal, pancreatic and hepatic carcinomas are characterized by high levels of matrix metalloproteinase (MMP)-2 and -9 secretions that degrade the ECM and basement membrane, allowing cancer cells ...
Created on 09 April 2015
95. Cytotoxic Effect of Lipophilic Substitution at 2-, 6-, and 2,6-Positions in Ascorbic Acid and Expression of Matrix Metalloproteinases in Hep G2 Cells, Melanoma Cells, and Normal Human Dermal Fibroblas ...
(Scientific Presentations: Cancer)
... of Nutrition, 22 (5):575, Abstract #43, October 2001. Comment Ascorbic acid and its derivatives have been shown to be cytotoxic and inhibit the growth of a number of malignant and non-malignant cell ...
Created on 04 April 2015
96. Inhibitory Effects of Ascorbic Acid, Proline, and Lysine Supplementation on Matrigel Invasion by Human Breast Cancer Cells MDA-MB-231
(Scientific Presentations: Cancer)
...   Comment The results from this study demonstrated that while an individual nutrient, such as ascorbic acid, can inhibit the invasion of cancer cells through Matrigel (a model for extracellular matrix), ...
Created on 04 April 2015
97. Metastatic and Cytoxic Effects of Ascobigen and Iso-Ascorbigen in Human Cancer Cell Lines
(Scientific Presentations: Cancer)
M.W. Roomi, A. Bogale, V. Ivanov, S. Netke, A. Niedzwiecki and M. Rath Presented at:  American College of Nutrition, 43rd Annual Meeting, San Antonio, Texas, Oct. 3-6, 2002. Published in:  J. Am. Coll. ...
Created on 04 April 2015
98. Nutrient Synergy – A Specific Formulation of Nutrients Containing Lysine, Proline, Ascorbic Acid, and Epigallocatechin Gallate Inhibits Matrix Metalloproteinases Activity and Invasion Potential of Human ...
(Scientific Presentations: Cancer)
... acid, lysine, proline, and epigallocatechin gallate significantly inhibited the metastasis potential of human melanoma, breast and liver cancer cells by inhibiting the expression of MMPs and Matrigel invasion, ...
Created on 04 April 2015
99. Inhibitory Effect of Nutrient Synergy, a Specific Formulation of Nutrients Containing Lysine, Proline, Ascorbic Acid, and Epigallocatechin Gallate, on Matrix Metalloproteinase Activity and Invasion of ...
(Scientific Presentations: Cancer)
... FASEB Journal, 17 (Part II, #5) p. A1368, Abstract #867:1, March 2003.   Comment To reproduce and spread to other parts in the body, cancer cells degrade the extracellular matrix (ECM) by secreting ...
Created on 04 April 2015
100. A Novel In Vitro Bioassay for Screening Matrix Metalloproteinase Activity in Human Cancer Cell Lines
(Scientific Presentations: Cancer)
... of the American Association for Cancer Research, 44:1045, Abstract #4559. Comment To reproduce and spread to other parts in the body, cancer cells degrade the extracellular matrix (ECM) by secreting ...
Created on 04 April 2015