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61. Phenolic compounds disrupt spike-mediated receptor-binding and entry of SARS-CoV-2 pseudo-virions
(Coronavirus)
... expression at protein level. Finally, each of these three compounds moderately increased endosomal/lysosomal pH. In conclusion, this study demonstrates pleiotropic anti-SARS-CoV-2 efficacy of specific ...
Created on 22 June 2021
62. Anti-borreliae efficacy of Gallic acid in vitro
(Scientific Presentations: Infectious Diseases)
... persisters, we have observed its significant nearly 99% biocidal effect in eliminating both these morphological forms of Borrelia burgdorferi s.s. and Borrelia garinii at 100 µg/ml concentration after ...
Created on 12 May 2021
63. Polyunsaturated ω‑3 fatty acids inhibit ACE2‑controlled SARS‑CoV‑2 binding and cellular entry
(Coronavirus)
... but neither of the fatty acids afected their expression at the protein level. Also, neither reduction of hACE2 activity nor binding to the hACE2 receptor upon treatment with these two fatty acids was observed. ...
Created on 05 May 2021
64. Inhibition of ACE2 expression by Ascorbic acid alone and its combination with other natural compounds
(Coronavirus)
... including a novel coronavirus 2019-nCoV. Limited availability of these receptors can thwart cellular entry of this virus. Methods: We tested the effects of ascorbic acid (vitamin C) on cellular expression ...
Created on 17 February 2021
65. The micronutrient combination with immune-enhancing effects
(Coronavirus)
... for novel non-toxic and effective approaches with immune system- enhancing effects, so it can resist and fight these infections is still sought after. It has been firmly established that both nutrition ...
Created on 08 October 2020
66. Vitamin C inhibits the calcification process in human vascular smooth muscle cells
(Heart Disease)
... accumulation in SMC-produced and -deposited extracellular matrix. These effects were accompanied by a reduction in cell-associated alkaline phosphatase activity. Significantly, treatment of cultured SMC ...
Created on 27 August 2020
67. Immunological targeting of matrix metalloproteinase-9 as a novel approach to universal cancer vaccine: Characterization of anticancer antibodies efficacy in vitro
(MMP)
... mouse MMP-9. All these peptides showed to be highly immunogenic in mice. Materials and Methods: The antibodies against mouse and rat MMP-9 oligopeptides were isolated and their effects on cancer cell ...
Created on 11 August 2020
68. Effective and safe global public health strategy to fight the COVID-19 pandemic: Specific micronutrient combination inhibits Coronavirus cell-entry receptor (ACE2) expression
(Publications)
... block several mechanisms of viral infections, we tested the efficacy of these natural compounds in suppressing the expression of the ACE2 receptor on human endothelial cells and small airway epithelial ...
Created on 02 July 2020
69. Scientific Breakthough Towards Natural Control of the Pandemic
(Publications)
... of viral infections, we tested the efficacy of these natural compounds in suppressing the expression of the ACE2 receptor on human endothelial cells and small airway epithelial cells. Our results show ...
Created on 29 June 2020
70. Effective and safe global public health strategy to fight the COVID-19 pandemic: Specific micronutrient composition inhibits Coronavirus cell-entry receptor (ACE2) expression
(Coronavirus)
... specific micronutrients can block several mechanisms of viral infections, we tested the efficacy of these natural compounds in suppressing the expression of the ACE2 receptor on human endothelial cells ...
Created on 29 June 2020
71. Matrix metalloproteinases-9 as a promising target for anti-cancer vaccine: inhibition of melanoma tumor growth in mice immunized with syngeneic MMP-9 peptides
(MMP)
... two oligopeptides from mouse MMP-9. All these peptides showed to be highly immunogenic in mice. Results: Subsequently, the immunized mice challenged with B16FO melanoma cells developed significantly ...
Created on 08 February 2020
72. Progress of Tumor Growth and Metastasis after Inoculation of B16FO Melanoma Cells in Kidney of Female Nude Mice Is Inhibited by a Novel Nutrient Mixture
(Skin Cancer)
... However, severe lung metastasis was observed in the control group and mild to moderate metastasis was observed in the NM group. Conclusion: These results show that the NM is effective in mitigating the ...
Created on 08 February 2020
73. In Vitro Effect of Cytokines, Inducers, and Inhibitors on the Secretion of MMP-2 and MMP-9 in Hepatocarcinoma Cell Line SK-Hep-1
(Gastrointestinal Cancers)
... control MMP activities. In this article, we investigated the roles of these in the regulation of MMP2, -9 secretions in HCC. Human HCC SK-Hep-1 was grown in appropriate media. At near confluence, the cells ...
Created on 08 February 2020
74. Synergistic Anti-Borreliae Efficacy of a Composition of Naturally-occurring Compounds: an In vitro Study
(Lyme Disease)
... its inhibitory effect on the release of IL-1α, IL-1β, and IL-6 by human CD14+ monocytes stimulated with live Borrelia sp. Conclusion:: These results suggest that such a formulation of compounds might ...
Created on 07 December 2019
75. Sathvika Gopalasetty
(Future Scientist)
... family members, are suffering due to the widespread diseases of diabetes and cancer. Sathvika believes that there is a dire need for research in these fields, and is inspired to conduct and publish research ...
Created on 20 September 2019
76. Vitamin C in Health: Scientific focus on its anti-cancer efficacy
(Other Aspects of Cancer)
... combination with other micronutrients such as lysine, arginine, proline and green tea extract. The synergistic effect of these nutrient mixtures can thus be considered in preventive and therapeutic aspects ...
Created on 23 August 2019
77. Diabetes in Children and the Role of Micronutrients
(Diabetes)
... addition, pharmacological treatments primarily developed and tested in adult diabetics carry health risks and are associated with unanticipated side effects when administered to children. All these concerns ...
Created on 23 August 2019
78. Chemotherapy docetaxel-derived tumor debris promotes growth of 4T1 breast cancer tumors in female nude mice by multiple mechanisms
(Breast Cancer)
... These toxic agents destroy both malignant and normal cells thereby increasing the population of dying cells and/or tumor debris and causing other changes in the tumor microenvironment. These dead cells ...
Created on 23 August 2019
79. Progress of Tumor Growth and Metastasis After Inoculation of B16FO Melanoma Cells in Kidney of Female Nude Mice Is Inhibited by a Novel Nutrient Mixture
(Skin Cancer)
...  These results show that the NM is effective in mitigating the growth of tumors in the kidney and metastases to the lung. Key words:  melanoma, B16FO, nutrient mixture, metastasis, tumor growth, female ...
Created on 08 May 2019
80. Inhibition of tumor growth and metastasis by a novel nutrient mixture of inoculation of mouse mammary 4T1 carcinoma in kidney of female Balb/c mice
(Breast Cancer)
... group was unaffected. Neither group showed any metastatic lesions in the liver or heart. In conclusion, these results suggest that the NM has the potential to suppress tumor growth and tumor metastasis ...
Created on 08 February 2019