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Chemotherapy docetaxel-derived tumor debris promotes growth of 4T1 breast cancer tumors in female nude mice by multiple mechanisms

M. W. Roomi, A. Niedzwiecki, M. Rath

Journal of Cellular Medicine and Natural Health, July 2019



Chemotherapy and radiation are basic cancer therapies aimed at reducing tumor burden. These toxic agents destroy both malignant and normal cells thereby increasing the population of dying cells and/or tumor debris and causing other changes in the tumor microenvironment. These dead cells can act as a source of stimulants on surviving tumor cells leading to recurrence of tumors, thereby reducing survival rates. We investigated the effects of docetaxel-induced debris of 4T1 cells—a murine breast cancer line—on breast tumor growth in female mice. Female athymic mice were divided into three groups.

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