Layer Slider

Slide backgroundSlide thumbnail
Slide backgroundSlide thumbnail
Slide backgroundSlide thumbnail

Slide backgroundTeamTeamTeam
Slide backgroundResearch TextResearch Text
Slide backgroundSlide thumbnail

Slide backgroundCell2Cell2
Slide backgroundVision1
Slide backgroundVideo2Video2

Research

Research

NewsPage

Clinical Support

Latest News

ICON L

Synergistic Anti-Borreliae Efficacy of a Composition of Naturally-occurring Compounds: an In vitro Study

A. Goc , A. Niedzwiecki, M. Rath

J Nutri Bio, 5(1): 350-363 (2019)

Abstract: Background: Borrelia sp., which is a pathogenic agent of Lyme diseases in mammals, has become an increasing problem worldwide due to the emergence of persistence. In this study we investigated whether a defined composition of naturally occurring substances could display a broad and synergistic action in vitro against both active and persistent forms of Borrelia spp.

Methods: A formulation of six plant-derived compounds combined at their 1/32-1/2 MIC values was tested in vitro against two species of Borrelia recognized as causative agents of Lyme disease in North America and Europe.

Results: The results showed that a composition of baicalein, luteolin, rosmarinic acid, monolaurin, cis-2-decenoic acid, and iodine at their 1/8 MIC values has significant synergistic effect against the active and persisting latent forms. This composition revealed anti-oxidative properties affecting Borrelia’s membrane but not DNA. Finally, we observed its inhibitory effect on the release of IL-1α, IL-1β, and IL-6 by human CD14+ monocytes stimulated with live Borrelia sp.

Conclusion:: These results suggest that such a formulation of compounds might be considered and further explored for its significant pleotropic anti-Borreliae efficacy. Additional in vivo and human studies are warranted to validate this possibility.

This article is protected by copyright. All rights reserved.

Key Words:
Borrelia spp, Persisters, Phytochemicals, Redox, Cytokines

Full Study: Printable