... disease cases. Targeting the APOE gene with nutrients and natural compounds could potentially benefit Alzheimer’s disease patients. In the search for such natural-derived compounds, we evaluated the effects ...

... work in this field has been done with individual compounds and directed towards their mechanisms of action or clinical applications. The interest in natural anti-microbial approaches has intensified ...

... by Staphylococcus aureus are currently a worldwide threat affecting millions of individuals. The pathogenicity of S. aureus is associated with numerous virulence factors, including cell surface proteins, ...

... and further revealed binding of TF3 to Hla with KD = 4.57×10−5 M. Interestingly, TF3 was also able to protect human primary keratino-cytes from Hla-induced cell death, being at the same time non-toxic ...

... individuals. New emerging variants of SARS-CoV-2, including Omicron and Arcturus, have been challenging the effectiveness of humoral immunity resulting from repeated vaccination and infection. With recent ...

... with morbidity and mortality from degenerative diseases. As different citrus compounds and fruit extracts provide a variety of physiological benefits and they are widely used in nutritional supplements ...

... RdRp, and identified the four fatty acids with the highest RdRp inhibitory potential. Among them, linoleic acid was found to have the greatest interaction with SARS-CoV-2 RdRp, with its direct binding ...

... have been increasing throughout Northern America and Europe. This pathogen, if not treated in a timely manner with antibiotics, can cause persisting and debilitating health outcomes. In the search for ...

... certain plant extracts (micronutrients) have been studied for their effects on diabetic metabolism. These studies, however, were largely conducted with individual micronutrients, thereby neglecting the ...

... on dietary vitamin C as an important antioxidant and as a cofactor in collagen synthesis, yet are prone to vitamin C deficiency. The brain is the one with the highest vitamin C content, owing to its high ...

... of five plant-derived compounds inhibited the attachment of the SARS-CoV-2 pseudo-typed particles with lung hACE2/A549 cells. In addition, it down-regulated the activity of key enzymes ...

... human lipoprotein(a) (Lp(a)) are two unique metabolic features present in humans, compared with most other animal species. The Gulo (-/-) and Lp(a)+ mouse model displays these two features and is therefore ...

... and curcumin displayed the highest binding with the receptor-binding domain of spike protein, inhibiting viral attachment to the human angiotensin-converting enzyme 2 receptor, and thus cellular entry ...

... and clinical studies indicate that a nutritious diet and/or intake of micronutrients with antioxidant, anti-inflammatory, and detoxifying properties, may ameliorate many harmful health effects caused by ...

... this combination of five plant-derived compounds inhibited the attachment of the SARS-CoV-2 pseudo-typed particles with lung hACE2/A549 cells. In addition, it inhibited the activity of key enzymes known ...

... experiment performed with cells pre-treated with Gallic acid and triple combination of mentioned antibiotics, respectively, yielded similar, i.e., 3-11% repopulation rate of viable cells. Based on the ...

... 2020. Although lipids have been shown to possess antiviral efcacy, little is currently known about lipid compounds with anti-SARS-CoV-2 binding and entry properties. To address this issue, we screened, ...

... by endothelial cells. Vitamin E with other vitamins resulted in either induction (E+C+A) or inhibition (E+D). The extracellular matrix deposition of type IV collagen and elastin by human aortic endothelial ...

Ivanov V, Ivanova S, Niedzwiecki A, Rath M Am J Cardiovasc Dis. 2020; 10(2): 108–116. Abstract: Vascular calcification is a pathophysiological process that is associated with coronary atherosclerosis, ...

... to human health as well as global economies. The quest for vaccines and other approaches to this pandemic thus far focuses on synthetic molecules that are – predictably – associated with a variable degree ...

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