- 81. L-lysine and vitamin C work better in synergy against Escherichia coli and Acinetobacter baumanniis
- (Infectious Disease)
- ... work in this field has been done with individual compounds and directed towards their mechanisms of action or clinical applications. The interest in natural anti-microbial approaches has intensified ...
- Created on 27 October 2023
- 82. Inhibitory effect of theaflavin-3,30 -digallate can involve its binding to the “stem” domain of α-hemolysin of Staphylococcus aureus
- (Infectious Disease)
- ... by Staphylococcus aureus are currently a worldwide threat affecting millions of individuals. The pathogenicity of S. aureus is associated with numerous virulence factors, including cell surface proteins, ...
- Created on 27 October 2023
- 83. Inhibition of α-hemolysin activity of Staphylococcus aureus by theaflavin 3,3’-digallate
- (Infectious Disease)
- ... and further revealed binding of TF3 to Hla with KD = 4.57×10−5 M. Interestingly, TF3 was also able to protect human primary keratino-cytes from Hla-induced cell death, being at the same time non-toxic ...
- Created on 06 September 2023
- 84. Phytochemicals and micronutrients in suppressing infectivity caused by SARS-CoV-2 virions and seasonal coronavirus HCoV-229E in vivo
- (Coronavirus)
- ... individuals. New emerging variants of SARS-CoV-2, including Omicron and Arcturus, have been challenging the effectiveness of humoral immunity resulting from repeated vaccination and infection. With recent ...
- Created on 02 June 2023
- 85. Cellular effects of citrus compounds
- (Others)
- ... with morbidity and mortality from degenerative diseases. As different citrus compounds and fruit extracts provide a variety of physiological benefits and they are widely used in nutritional supplements ...
- Created on 04 January 2023
- 86. Linoleic acid binds to SARS‑CoV‑2 RdRp and represses replication of seasonal human coronavirus OC43
- (Coronavirus)
- ... RdRp, and identified the four fatty acids with the highest RdRp inhibitory potential. Among them, linoleic acid was found to have the greatest interaction with SARS-CoV-2 RdRp, with its direct binding ...
- Created on 16 November 2022
- 87. Inhibition of Borrelia Burgdorferi-Induced TLR2-NFκB Canonical Signaling by Gallic Acid through Targeting the CD14+ Adaptor Protein and p65 Molecule
- (Lyme Disease)
- ... have been increasing throughout Northern America and Europe. This pathogen, if not treated in a timely manner with antibiotics, can cause persisting and debilitating health outcomes. In the search for ...
- Created on 26 September 2022
- 88. Health Benefits of Specific Micronutrient Combinations in Diabetes
- (Diabetes)
- ... certain plant extracts (micronutrients) have been studied for their effects on diabetic metabolism. These studies, however, were largely conducted with individual micronutrients, thereby neglecting the ...
- Created on 31 March 2022
- 89. Age and Dietary Vitamin C Intake Affect Brain Physiology in Genetically Modified Mice Expressing Human Lipoprotein(A) and Unable to Synthesize Vitamin C
- (Aging)
- ... on dietary vitamin C as an important antioxidant and as a cofactor in collagen synthesis, yet are prone to vitamin C deficiency. The brain is the one with the highest vitamin C content, owing to its high ...
- Created on 24 December 2021
- 90. Simultaneous Inhibition of SARS-CoV-2 Infectivity by a Specific Combination of Plant-derived Compounds
- (Coronavirus)
- ... of five plant-derived compounds inhibited the attachment of the SARS-CoV-2 pseudo-typed particles with lung hACE2/A549 cells. In addition, it down-regulated the activity of key enzymes ...
- Created on 23 September 2021
- 91. Dietary Vitamin C and Age-Induced Lipid and Hormonal Metabolic Changes in a Humanized Mouse Model Not Synthesizing Vitamin C and Producing Lipoprotein(a) [Gulo (−/−); Lp(a)+]
- (Aging)
- ... human lipoprotein(a) (Lp(a)) are two unique metabolic features present in humans, compared with most other animal species. The Gulo (-/-) and Lp(a)+ mouse model displays these two features and is therefore ...
- Created on 23 June 2021
- 92. Phenolic compounds disrupt spike-mediated receptor-binding and entry of SARS-CoV-2 pseudo-virions
- (Coronavirus)
- ... and curcumin displayed the highest binding with the receptor-binding domain of spike protein, inhibiting viral attachment to the human angiotensin-converting enzyme 2 receptor, and thus cellular entry ...
- Created on 22 June 2021
- 93. Micronutrients in mitigating the adverse health effects of air pollution – part 2
- (Others)
- ... and clinical studies indicate that a nutritious diet and/or intake of micronutrients with antioxidant, anti-inflammatory, and detoxifying properties, may ameliorate many harmful health effects caused by ...
- Created on 11 June 2021
- 94. Simultaneous inhibition of key mechanisms of SARS-CoV-2 infectivity by a specific combination of polyphenols
- (Scientific Presentations: Infectious Diseases)
- ... this combination of five plant-derived compounds inhibited the attachment of the SARS-CoV-2 pseudo-typed particles with lung hACE2/A549 cells. In addition, it inhibited the activity of key enzymes known ...
- Created on 14 May 2021
- 95. Anti-borreliae efficacy of Gallic acid in vitro
- (Scientific Presentations: Infectious Diseases)
- ... experiment performed with cells pre-treated with Gallic acid and triple combination of mentioned antibiotics, respectively, yielded similar, i.e., 3-11% repopulation rate of viable cells. Based on the ...
- Created on 12 May 2021
- 96. Polyunsaturated ω‑3 fatty acids inhibit ACE2‑controlled SARS‑CoV‑2 binding and cellular entry
- (Coronavirus)
- ... 2020. Although lipids have been shown to possess antiviral efcacy, little is currently known about lipid compounds with anti-SARS-CoV-2 binding and entry properties. To address this issue, we screened, ...
- Created on 05 May 2021
- 97. Fat Soluble vitamins affect composition of extracellular matrix deposited by human aortic smooth muscle and endothelial cells in vitro
- (Heart Disease)
- ... process that is associated with coronary atherosclerosis, and is a prognostic marker of cardiovascular morbidity and mortality. The process of arterial wall calcification is triggered and accompanied by ...
- Created on 28 August 2020
- 98. Vitamin C inhibits the calcification process in human vascular smooth muscle cells
- (Heart Disease)
- ... muscle cells increased by vitamin C and its combination (C+D+E). β-carotene + D + C induced the extracellular matrix deposition of collagen I by endothelial cells. Vitamin E with other vitamins resulted ...
- Created on 27 August 2020
- 99. Micronutrient combination inhibits two key steps of coronavirus (SARS-CoV-2) infection: viral binding to ACE2 receptor and its cellular expression
- (Coronavirus)
- ... to human health as well as global economies. The quest for vaccines and other approaches to this pandemic thus far focuses on synthetic molecules that are – predictably – associated with a variable degree ...
- Created on 27 August 2020
- 100. Immunological targeting of matrix metalloproteinase-9 as a novel approach to universal cancer vaccine: Characterization of anticancer antibodies efficacy in vitro
- (MMP)
- ... door for effective prevention and even cure. We previously reported that mice immunized with synthetic oligopeptides containing specific amino acid sequences from human MMP-2 and MMP-9 showed a significant ...
- Created on 11 August 2020