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81. Effects of Various Multi-Nutrient Supplements on the Production and Extracellular Deposition of Collagen I and IV by Human Aortic Smooth Muscle Cells
(Heart Disease)
... vascular wall, which over decades can lead to the development of CVD.1,7 Vitamin and mineral supplements are designed to fill the gap in quality of everyday food by providing these and other essential ...
Created on 28 January 2019
82. A Novel Nutrient Mixture Induces Apoptosis in Human Ovarian and Cervical Cancer Cells
(Female Reproductive Cancer)
... patients has dropped to 15-20% when these cancers metastasize to  distant  organs.  A  unique  formulation  of  nutrients  containing  green  tea  extract,  ascorbic  acid,  lysine  and  proline,  has ...
Created on 28 January 2019
83. Peptide vaccines directed against human Metalloproteinases (MMPs) with anti-tumor efficacy in vitro and in vivo
(Other Aspects of Cancer)
... develop an anti-cancer vaccine by inhibiting these specific enzymes. We selected three oligopeptides from human MMP-9 and one from human MMP-2. We demonstrated the efficacy of these oligopeptides in generating ...
Created on 23 January 2019
84. Down regulation of u-Pa by a nutrient mixture In hemangioma (eoma) cells by inducing Caspase-dependent apoptosis
(Other Aspects of Cancer)
... changes than the control or camptothecin-treated cells. Conclusion: These results suggest NM as a potential therapeutic agent as it specifically targets and induces apoptosis in hemangioma cells. Key ...
Created on 19 June 2018
85. Reciprocal cooperation of phytochemicals and micronutrients against typical and atypical forms of Borrelia spp.
(Lyme Disease)
... permeability of Borrelia spp. but did not cause DNA damage. Conclusions: These results show that a specific combination of flavones might play a supporting role in combating Borrelia spp. through either ...
Created on 23 June 2017
86. In vitro Evaluation of Non-synthetic Compounds against Biofilm of Streptococcus mutans
(Scientific Presentations: Infectious Diseases)
... italicum extract have eradicated 80% of mature biofilm. Moreover, treatments with these agents significantly disrupted EPS content within biofilms validating anti-biofilm action of these compounds. Therefore, ...
Created on 20 June 2017
87. Composition of Plant-derived Compounds as an Alternative Approach to Lyme disease
(Scientific Presentations: Infectious Diseases)
... in vitro tested individually and in combinations against active and persistent forms of B. burgdorferi (prevalent in the USA) and B. garrini (prevalent in Europe). Several of these compounds, individually ...
Created on 20 June 2017
88. Modulation of MMP-2 and -9 Secretion by Cytokines, Inducers and Inhibitors in Human Melanoma A-2058 Cells
(Skin Cancer)
... inducers and inhibitors control MMP activities. We investigated the roles of these in regulation of MMP-2 and -9 in human melanoma A-2058 cells. Human A-2058 cells were grown in DMEM supplemented with ...
Created on 26 April 2017
89. Modulation of MMP-2 and MMP-9 secretion by cytokines, inducers and inhibitors in human glioblastoma T-98G cells
(Head & Neck Cancers)
... to spread to distal organs. Various cytokines, mitogens, growth factors, inducers and inhibitors control MMP activity. We investigated the roles of these in the regulation of MMP-2 and MMP-9 in human glioblastoma ...
Created on 28 March 2017
90. Nutrient Synergy: A Novel Approach To Head And Neck Cancer (Chapter 1)
(Head & Neck Cancers)
... with progression and invasion of these tumors. In our studies we targeted various mechanisms of cancer by designing specific combinations of different polyphenols (PB) and combinations of polyphenols with ...
Created on 28 March 2017
91. Cytokines, Inducers And Inhibitors Modulate Mmp-2 And Mmp‑9 Secretion By Human Fanconi Anemia Immortalized Fibroblasts
(Head & Neck Cancers)
... and MMP-9, have been implicated in tumor invasion and metastasis. Various cytokines, mitogens, growth factors, inducers and inhibitors control MMP activities. We investigated the roles of these in the ...
Created on 28 March 2017
92. A Specific Mixture Of Nutrients Suppresses Ovarian Cancer A-2780 Tumor Incidence, Growth, And Metastasis To Lungs
(Female Reproductive Cancer)
... Matrigel with total block at 250 μg/mL concentration. MTT showed dose-dependent inhibition of cell proliferation with EPQ, and H & E staining showed no morphological changes below 500 μg/mL EPQ. These ...
Created on 20 March 2017
93. In Vitro Modulation of MMP-2 and MMP-9 Secretion by Cytokines, Inducers, and Inhibitors in Head and Neck Squamous Carcinoma Cells (FaDu) and Tongue Carcinoma Cells (SCC-25)
(Head & Neck Cancers)
... and quantitatively analyzed by densitometry. Our results showed that these agents have an up and down regulating effect on MMP-2 and MMP-9 secretion, suggesting the clinical usage of these agents may be ...
Created on 06 February 2017
94. Effects of Ascorbic Acid on Tax, NF-κB and MMP-9 in Human T-cell Lymphotropic Virus Type 1 Positive Malignant T-Lymphocytes
(Blood Cancer)
... two cell lines. Conclusion: These results indicated that while AA exerted its anti-proliferative effect on the NF- κB activation pathway by suppressing Tax expression, its effects on MMP9 seemed to be ...
Created on 05 January 2017
95. Cooperation of Doxycycline with Phytochemicals and Micronutrients Against Active and Persistent Forms of Borrelia sp
(Lyme Disease)
... be explored further in defining more effective treatments against these bacteria. This article is protected by copyright. All rights reserved. Key Words: Borrelia sp., spirochetes, cysts, biofilm, ...
Created on 19 September 2016
96. The anti-borreliae efficacy of phytochemicals and micronutrients: an update
(Lyme Disease)
... of these bacteria and help improve the efficacy of current approaches against Lyme disease. Here, we review all naturally occurring substances scientifically evaluated to date, including plant extracts, ...
Created on 19 September 2016
97. Lipoprotein(A) And Vitamin C Impair Development Of Breast Cancer Tumors In Lp(A)+; Gulo-/- Mice
(Breast Cancer)
... C synthesis and the production of human Lp(a).  Female Lp(a)+;Gulo(-/-) and control wild type Balb/c mice without these two metabolic features were orthotopically inoculated with 4T1 breast cancer cells ...
Created on 04 July 2016
98. Reciprocal Cooperation of Phytochemicals against Borrelia burgdorferi and Borrelia garinii
(Scientific Presentations: Infectious Diseases)
... Antibacterial effects of these agents’ cooperation were evaluated at their MIC values and three dilutions above (2-6 X MIC) as well as three dilutions below their MICs (1/2-1/8 X MIC), according to checkerboard ...
Created on 20 June 2016
99. Evaluation of Vitamin D3 and Vitamin C in Cooperation with Doxycycline against Borrelia burgdorferii and Borrlia garinii
(Scientific Presentations: Infectious Diseases)
... forms of Borrelia burgdorferi and Borrelia garinii using dark field and fluorescence microscope. Synergistic antibacterial effect of these agents was evaluated at their MIC values and three dilutions above ...
Created on 16 June 2016
100. New Non-synthetic Antibacterial Agents Challenging the Active and Persistent Forms of Borrelia ssp.
(Scientific Presentations: Infectious Diseases)
... different persistent forms. Thus, there is a continuous search for new compounds that would be effective not only against spirochetes but also these persisters. Naturally occurring agents signify a growing ...
Created on 16 May 2016