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Our newly discovered benefits of natural compounds including

daidzein and inositol in controlling important mechanisms

associated with Alzheimer's disease and other brain pathologies.

Natural Compounds Modulate Apolipoprotein E Gene and Protein

Expression in Fibroblasts Derived from Young and Old Female Alzheimer’s Patients

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The anti-borreliae efficacy of phytochemicals and micronutrients: an update

Anna Goc and Matthias Rath

Therapeutic Advances in Infectious Disease 2016, 3(3-4): 75-82

Abstract: Naturally occurring substances have been used for centuries to fight against various pathogens. They serve as a source for new chemical entities or provide options to already existing therapeutics. While there is an increasing interest in studying antimicrobial properties of naturally derived agents, little is known about their effects against Borrelia burgdorferi sensu lato, the causative pathogens of Lyme disease.

A better understanding of this aspect could advance knowledge about pathophysiology of these bacteria and help improve the efficacy of current approaches against Lyme disease. Here, we review all naturally occurring substances scientifically evaluated to date, including plant extracts, their metabolites, and micronutrients, against vegetative (spirochetes) and latent (rounded bodies, biofilm) forms of Borrelia sp. This summary reveals the potent anti-borreliae activity of several of these natural compounds indicating their potential in enhancing the efficacy of current treatments for Lyme disease, and offering new options to already existing therapeutic regiments.

This article is protected by copyright. All rights reserved.

Key Words:
biofilm, Borrelia sp., cysts, micronutrients, phytochemicals, spirochetes

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