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61. Age and Dietary Vitamin C Intake Affect Brain Physiology in Genetically Modified Mice Expressing Human Lipoprotein(A) and Unable to Synthesize Vitamin C
(Aging)
... oxygen consumption and oxidative stress. It has been shown that brain aging is accompanied by accumulated oxidative damage, which can lead to memory decline and neurological diseases. Objective: Our ...
Created on 24 December 2021
62. Simultaneous Inhibition of SARS-CoV-2 Infectivity by a Specific Combination of Plant-derived Compounds
(Coronavirus)
... pandemic remains a challenge to human health and economy worldwide. Previously we have shown that a combination of active plant-derived compounds and plant extracts can dose-dependently inhibit binding ...
Created on 23 September 2021
63. Dietary Vitamin C and Age-Induced Lipid and Hormonal Metabolic Changes in a Humanized Mouse Model Not Synthesizing Vitamin C and Producing Lipoprotein(a) [Gulo (−/−); Lp(a)+]
(Aging)
... suitable for the study of metabolic aspects relevant to human metabolism. It is a well-known fact that vitamin C is essential in collagen synthesis, and in maintaining extracellular matrix integrity, as ...
Created on 23 June 2021
64. Phenolic compounds disrupt spike-mediated receptor-binding and entry of SARS-CoV-2 pseudo-virions
(Coronavirus)
... to the host receptor in order to prevent its entry has been of particular interest. Here, we provide experimental evidence that, among 56 tested polyphenols, including plant extracts, brazilin, theaflavin-3,3’-digallate, ...
Created on 22 June 2021
65. Micronutrients in mitigating the adverse health effects of air pollution – part 2
(Others)
... disease (COPD), lung cancer, and acute lower respiratory infections in children. Yet, 92% of the world population lives in places that exceed the WHO air quality guidelines. On the other hand, laboratory ...
Created on 11 June 2021
66. Simultaneous inhibition of key mechanisms of SARS-CoV-2 infectivity by a specific combination of polyphenols
(Scientific Presentations: Infectious Diseases)
... pandemic remains a challenge to human health and economy worldwide. Previously we have shown that a combination of active plant-derived compounds and plant extracts can dose-dependently inhibit binding ...
Created on 14 May 2021
67. Anti-borreliae efficacy of Gallic acid in vitro
(Scientific Presentations: Infectious Diseases)
... still sought after due to the growing number of newly infected patients or those that relapse after discontinuation of antibiotic application. In this study, we investigated whether a trihydroxybenzoic ...
Created on 12 May 2021
68. Polyunsaturated ω‑3 fatty acids inhibit ACE2‑controlled SARS‑CoV‑2 binding and cellular entry
(Coronavirus)
... sequence, we observed that polyunsaturated fatty acids most efectively interfere with binding to hACE2, the receptor for SARSCoV-2. Using a spike protein pseudo-virus, we also found that linolenic acid ...
Created on 05 May 2021
69. Inhibition of ACE2 expression by Ascorbic acid alone and its combination with other natural compounds
(Coronavirus)
... compounds can affect ACE2 expression. Results: The results show that ascorbic acid itself has moderate but consistent lowering effects on ACE2 expression at the cellular, protein, and RNA levels. Some ...
Created on 17 February 2021
70. Scientific basis of micronutrient applications as an effective, safe, and affordable global public health strategy to help control the coronavirus pandemic
(Coronavirus)
... and energy, among many other aspects. 2 This statement highlights the important, but often overlooked, fact that healthy nutrition supplying a full spectrum of micronutrients is the foundation of our immune ...
Created on 02 February 2021
71. The micronutrient combination with immune-enhancing effects
(Coronavirus)
... for novel non-toxic and effective approaches with immune system- enhancing effects, so it can resist and fight these infections is still sought after. It has been firmly established that both nutrition ...
Created on 08 October 2020
72. Vitamin C inhibits the calcification process in human vascular smooth muscle cells
(Heart Disease)
Ivanov V, Ivanova S, Niedzwiecki A, Rath M Am J Cardiovasc Dis. 2020; 10(2): 108–116. Abstract: Vascular calcification is a pathophysiological process that is associated with coronary atherosclerosis, ...
Created on 27 August 2020
73. Micronutrient combination inhibits two key steps of coronavirus (SARS-CoV-2) infection: viral binding to ACE2 receptor and its cellular expression
(Coronavirus)
... to human health as well as global economies. The quest for vaccines and other approaches to this pandemic thus far focuses on synthetic molecules that are – predictably – associated with a variable degree ...
Created on 27 August 2020
74. Immunological targeting of matrix metalloproteinase-9 as a novel approach to universal cancer vaccine: Characterization of anticancer antibodies efficacy in vitro
(MMP)
... door for effective prevention and even cure. We previously reported that mice immunized with synthetic oligopeptides containing specific amino acid sequences from human MMP-2 and MMP-9 showed a significant ...
Created on 11 August 2020
75. Effective and safe global public health strategy to fight the COVID-19 pandemic: Specific micronutrient combination inhibits Coronavirus cell-entry receptor (ACE2) expression
(Publications)
... a fact documented in every leading textbook of biology.  This study provides scientific evidence that, in addition, specific micronutrient compositions are powerful tools in the fight against the COVID-19 ...
Created on 02 July 2020
76. Scientific Breakthough Towards Natural Control of the Pandemic
(Publications)
... in every leading textbook of biology.  This study provides scientific evidence that, in addition, specific micronutrient combination are powerful tools in the fight against the COVID-19 pandemic. Both, ...
Created on 29 June 2020
77. Effective and safe global public health strategy to fight the COVID-19 pandemic: Specific micronutrient composition inhibits Coronavirus cell-entry receptor (ACE2) expression
(Coronavirus)
... general immune resistance against infections, a fact documented in every leading textbook of biology.  This study provides scientific evidence that, in addition, specific micronutrient compositions are ...
Created on 29 June 2020
78. Specific composition of polyphenolic compounds with fatty acids as an approach in helping to reduce spirochete burden in Lyme disease: in vivo and human observational study
(Lyme Disease)
...  Methods: To determine a suitable approach that would help reduce this number, we examined the efficacy of a composition of polyphenolic compounds (baicalein, luteolin, and rosmarinic acid) with fatty ...
Created on 13 June 2020
79. Expanding Metabolic Targets in Cancer by Select Combinations of Vitamin C and EGCG with Different Natural Compounds
(Other Aspects of Cancer)
... can overcome the metabolic limitations of individual components and enhance the scope of their therapeutic efficacy. In this aspect, our in vitro and in vivo studies have shown that synergy-based interaction ...
Created on 08 February 2020
80. Matrix metalloproteinases-9 as a promising target for anti-cancer vaccine: inhibition of melanoma tumor growth in mice immunized with syngeneic MMP-9 peptides
(MMP)
... could open the door for effective prevention and even cure. We previously reported that mice immunized with synthetic oligopeptides containing specific amino acid sequences from human MMP-2 and MMP-9 showed ...
Created on 08 February 2020