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Peptide vaccines directed against human Metalloproteinases (MMPs) with anti-tumor efficacy in vitro and in vivo

M. W. Roomi, A. Niedzwiecki, M. Rath

Journal of Cellular Medicine and Natural Health, Oct 2018

 

Despite sporadic progress, cancer has thus far eluded preventive and therapeutic approaches that can lead to an effective control of this global epidemic. The single most important reason for this failure is the fact that no effective intervention became available to impede the pathological pathways common to all types of cancer. In our study, we targeted metalloproteinases (MMPS), endopeptidases that are involved in the breakdown of extracellular matrix (ECM). Among them, MMP-2 and MMP-9 are critically involved in all stages of cancer development including tumor growth, invasion and metastasis.

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