M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath
Experimental Lung Research 2006, 32(9):441-453

Introduction:
The high incidence of lung cancer and ineffective toxic action of current mono and doublet chemotherapy approaches result in poor patient survival. Enzymes called matrix metalloproteinases (MMPs), which degrade the extracellular matrix are implicated in neoplastic invasion and metastasis. A nutrient mixture (NM) containing lysine, proline, arginine, ascorbic acid, and green tea extract has shown significant antitumor effects, including inhibition of MMPs and invasion. Based on this, we investigated the effect of NM on human lung carcinoma cell A-549 cells in vitro and in vivo.