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61. Cardiovascular Effects of Cyclical Dietary Vitamin C Withdrawal in Mice Deficient in Internal Synthesis of Vitamin C and producing human lipoprotein (a): Gulo(-/-); Lp(a)+
(Heart Disease)
...  Background: Scientific knowledge of the impact of periodic dietary vitamin C intake and withdrawal on the development of cardiovascular disease has been limited. Our earlier study using a transgenic ...
Created on 29 January 2019
62. Lipoprotein(A) And Vitamin C Impair Development Of Breast Cancer Tumors In Lp(A)+; Gulo-/- Mice
(Breast Cancer)
... the precise mechanisms of ECM degradation in cancer we used a genetically modified mouse mimicking two distinct human metabolic features associated with cancerogenesis - the lack of endogenous vitamin ...
Created on 04 July 2016
63. Evaluation of Vitamin D3 and Vitamin C in Cooperation with Doxycycline against Borrelia burgdorferii and Borrlia garinii
(Scientific Presentations: Infectious Diseases)
... SATURDAY-441 Background: Little is known about the anti-borrelieae activity of vitamins with commercially available agents against spirochetes of Borrelia sp. that cause Lyme disease. To better understand ...
Created on 16 June 2016
64. New Research in Influenza: It's More Than Just Vitamin C
(Health Science News Page)
... vitamin C has been a popular remedy against the flu. However, our research has documented that vitamin C combined with lysine and other micronutrients such as proline, green tea extract, and N-Acetylcysteine, ...
Created on 10 April 2015
65. Lipoprotein(A) And Vitamin C Affect The Development Of Breast Cancer Tumors In LP(A)+; GULO-/- Mice
(Scientific Presentations: Cancer)
... in humans and primates, the species which lost an ability to synthesize vitamin C endogenously. We have shown earlier that Lp(a), due to its strong ECM binding properties, may be considered a biological ...
Created on 04 April 2015
66. A Randomized, Double-Blind Placebo-Controlled Clinical Study Documents the Benefits of a Vitamin Program as an Adjunct Therapy in Patients With Paroxysmal Atrial Arrhythmia
(Scientific Presentations: Heart Disease)
Niedzwiecki A, Rath M Presented at:  14th Madrid Arrhythmia Meeting, Madrid, Spain, February 27-28, 2003. Published in:  Conference Proceedings.   Comment The combination of vitamins, minerals ...
Created on 02 April 2015
67. Reduction in the Frequency of Arrhythmic Episodes in Patients with Paroxysmal Atrial Arrhythmia with a Vitamin/Essential Nutrient Program
(Clinical Studies tab)
A. Niedzwiecki, T. Kalinovsky, M. Rath Journal of the American Neutraceutical Association 2005, 8(3): 19-25 Introduction: Chronic deficiency of vitamins and other essential nutrients impairs cellular ...
Created on 14 March 2015
68. Ascorbate Depletion Increases Growth and Metastasis of Melanoma Cells in Vitamin C Deficient Mice
(Skin Cancer)
... and metastasis and has been found to correlate with the aggressiveness of tumor growth and invasiveness of the cancer. Vitamin C, synthesized by many animals but not by humans, is known to be essential ...
Created on 08 March 2015
69. Ascorbate supplementation inhibits growth and metastasis of B16FO melanoma and 4T1 breast cancer cells in vitamin C deficient mice
(Breast Cancer)
J. Cha, M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki and M. Rath Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050 International Journal of Oncology 2013,  42: 55-64 Abstract ...
Created on 07 March 2015
70. Natural Compounds Modulate Apolipoprotein E Gene and Protein Expression in Fibroblasts Derived from Young and Old Female Alzheimer’s Patients
(New Publications)
... of soy-derived estrogenic compounds such as genistein and daidzein, phospholipid precursors such as inositol and choline, phospholipid phosphatidylserine, and vitamins C and E as potent antioxidants on ...
Created on 22 May 2024
71. Cellular effects of fruit extracts and their active components applied individually and in combinations
(New Publications)
... rich in vitamins, minerals and bioflavonoids is essential for general health. Since many people fail to meet those consumption targets, there is a huge industry marketing fruit juices, extracts and blends, ...
Created on 28 February 2023
72. Linoleic acid binds to SARS‑CoV‑2 RdRp and represses replication of seasonal human coronavirus OC43
(Coronavirus)
... little is yet known about their effect on replication of human coronaviruses. To shed light on this subject, we first screened 15 fatty acids, three lipid-soluble vitamins, and cholesterol, on SARSCoV-2 ...
Created on 16 November 2022
73. Composition of naturally occurring compounds decreases activity of Omicron and SARS-CoV-2 RdRp complex
(Coronavirus)
... vitamin C, N-acetylcysteine, resveratrol, theaflavin, curcumin, quercetin, naringenin, baicalin, and broccoli extract showed to inhibit activity of RdRp/nsp7/nsp8 both these variants. In vitro exposure ...
Created on 24 August 2022
74. Inhibitory effects of specific combination of natural compounds against SARS-CoV-2 and its Alpha, Beta, Gamma, Delta, Kappa, and Mu variants
(Coronavirus)
... Delta, Kappa,and Mu variants. The composition containing vitamin C, N-acetylcysteine, resveratrol, theaflavin, curcumin, quercetin, naringenin, baicalin, and broccoli extract demonstrated a highest efficacy ...
Created on 18 August 2022
75. Health Benefits of Specific Micronutrient Combinations in Diabetes
(Diabetes)
... superior synergetic effects of these bioactive molecules in the prevention and therapy of diabetes.   Our study shows that specific combinations of vitamins, minerals and other active plant derived ...
Created on 31 March 2022
76. Micronutrients in mitigating the adverse health effects of air pollution – part 2
(Others)
... polluted air. Part II presents an overview of potential biological mechanisms underlying the protective effects of vitamins B, C, and E, omega-3 fatty acids, and sulforaphane against air pollutants, as ...
Created on 11 June 2021
77. Polyunsaturated ω‑3 fatty acids inhibit ACE2‑controlled SARS‑CoV‑2 binding and cellular entry
(Coronavirus)
... overall, 17 polyunsaturated fatty acids, monounsaturated fatty acids and saturated fatty acids, as wells as lipid-soluble vitamins. In performing target-based ligand screening utilizing the RBD-SARS-CoV-2 ...
Created on 05 May 2021
78. Inhibition of ACE2 expression by Ascorbic acid alone and its combination with other natural compounds
(Coronavirus)
... including a novel coronavirus 2019-nCoV. Limited availability of these receptors can thwart cellular entry of this virus. Methods: We tested the effects of ascorbic acid (vitamin C) on cellular expression ...
Created on 17 February 2021
79. The micronutrient combination with immune-enhancing effects
(Coronavirus)
... cells to various challenges. The results showed that some vitamins, minerals, and plant extracts had significant enhancing effects on specific immune responses tested in this study. However, a combination ...
Created on 08 October 2020
80. Effective and safe global public health strategy to fight the COVID-19 pandemic: Specific micronutrient combination inhibits Coronavirus cell-entry receptor (ACE2) expression
(Publications)
... cells. Our results show that a micronutrient composition comprising vitamin C as well as certain amino acids, polyphenols, and trace elements is able to suppress this viral ‘entry door’ into the body ...
Created on 02 July 2020