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61. L-lysine and vitamin C work better in synergy against Escherichia coli and Acinetobacter baumanniis
(New Publications)
W. Sumera, A. Niedzwiecki Journal of Cellular Medicine and Natural Health, Jun 22, 2023 Abstract: For centuries various plants and their natural compounds were used as antimicrobial agents. Most research ...
Created on 27 October 2023
62. Cellular effects of citrus compounds
(Others)
... and food products. However, there are no systematic studies comparing their efficacy at a cellular level. Methods and results: In this study, we evaluated the efficacy of select citrus fruit extracts ...
Created on 04 January 2023
63. Linoleic acid binds to SARS‑CoV‑2 RdRp and represses replication of seasonal human coronavirus OC43
(Coronavirus)
Goc A, Sumera W, Rath M, Niedzwiecki A. Scientific Reports 2022, 12:19114 Abstract Fatty acids belong to a group of compounds already acknowledged for their broad antiviral efficacy. However, ...
Created on 16 November 2022
64. Composition of naturally occurring compounds decreases activity of Omicron and SARS-CoV-2 RdRp complex
(Coronavirus)
Goc A, Niedzwiecki A, Rath M. European Journal of Microbiology and Immunology, June 2022 Abstract Naturally-occurring compounds are acknowledged for their broad antiviral efficacy. Little is however ...
Created on 24 August 2022
65. Inhibitory effects of specific combination of natural compounds against SARS-CoV-2 and its Alpha, Beta, Gamma, Delta, Kappa, and Mu variants
(Coronavirus)
... administrated to human pulmonary cells resulted in up to 60% inhibition in their cellular entry. Additionally, this composition significantly inhibited other cellular mechanisms of viral infectivity, including ...
Created on 18 August 2022
66. Health Benefits of Specific Micronutrient Combinations in Diabetes
(Diabetes)
... certain plant extracts (micronutrients) have been studied for their effects on diabetic metabolism. These studies, however, were largely conducted with individual micronutrients, thereby neglecting the ...
Created on 31 March 2022
67. Simultaneous Inhibition of SARS-CoV-2 Infectivity by a Specific Combination of Plant-derived Compounds
(Coronavirus)
... known to be crucial for the entry of the SARS-CoV-2 virus, such as TMPRSS2, furin and cathepsin L, but not their expression at protein level. This combination did not affect ACE2 binding to and ACE2 enzymatic ...
Created on 23 September 2021
68. Phenolic compounds disrupt spike-mediated receptor-binding and entry of SARS-CoV-2 pseudo-virions
(Coronavirus)
Goc A, Sumera W, Rath M, Niedzwiecki A PLOS ONE 16(6): e0253489. 2021 Abstract In the pursuit of suitable and effective solutions to SARS-CoV-2 infection, we investigated the efficacy of several ...
Created on 22 June 2021
69. Simultaneous inhibition of key mechanisms of SARS-CoV-2 infectivity by a specific combination of polyphenols
(Scientific Presentations: Infectious Diseases)
... to be crucial for the entry of the SARS-CoV-2 virus, such as TMPRSS2, furin and cathepsin L, but not their expression at protein level. This combination did not affect ACE2 binding to and ACE2 enzymatic ...
Created on 14 May 2021
70. Anti-borreliae efficacy of Gallic acid in vitro
(Scientific Presentations: Infectious Diseases)
... acid known as Gallic acid, and representative of phenolic acid, could become such an alternative. Using microscopic and spectrofluorometric methods against typical motile spirochetes and their knob/round-shaped ...
Created on 12 May 2021
71. Polyunsaturated ω‑3 fatty acids inhibit ACE2‑controlled SARS‑CoV‑2 binding and cellular entry
(Coronavirus)
... but neither of the fatty acids afected their expression at the protein level. Also, neither reduction of hACE2 activity nor binding to the hACE2 receptor upon treatment with these two fatty acids was observed. ...
Created on 05 May 2021
72. Immunological targeting of matrix metalloproteinase-9 as a novel approach to universal cancer vaccine: Characterization of anticancer antibodies efficacy in vitro
(MMP)
... mouse MMP-9. All these peptides showed to be highly immunogenic in mice. Materials and Methods: The antibodies against mouse and rat MMP-9 oligopeptides were isolated and their effects on cancer cell ...
Created on 11 August 2020
73. Effective and safe global public health strategy to fight the COVID-19 pandemic: Specific micronutrient combination inhibits Coronavirus cell-entry receptor (ACE2) expression
(Publications)
... population is compromised and unable to resist an aggressive virus or other pathogen. The only scientifically proven way for humans to strengthen their immune system in general and better resist a multitude ...
Created on 02 July 2020
74. Scientific Breakthough Towards Natural Control of the Pandemic
(Publications)
... and unable to resist an aggressive virus or other pathogen. The only scientifically proven way for humans to strengthen their immune system in general and better resist a multitude of infective agents, ...
Created on 29 June 2020
75. Specific composition of polyphenolic compounds with fatty acids as an approach in helping to reduce spirochete burden in Lyme disease: in vivo and human observational study
(Lyme Disease)
... therapeutic approach to this disease is limited to antibiotics. However, after their administration, about 20% of patients experience delayed onset of this illness manifesting as lingering persistent symptoms. ...
Created on 13 June 2020
76. Nutritional Deficiencies in Young People: Causes, Consequences and Strategies
(Others)
... to late twenties rarely cause concern. However, this stage of life can be challenging for many reasons. As young men and women push their bodies to achieve athletic, aesthetic and professional goals, they ...
Created on 01 May 2020
77. Expanding Metabolic Targets in Cancer by Select Combinations of Vitamin C and EGCG with Different Natural Compounds
(Other Aspects of Cancer)
... to have antioxidant and anticancer properties. However, individual compounds have limited anticancer efficacy as compared to their use in combinations. In this chapter, we describe the efficacy of ...
Created on 08 February 2020
78. In Vitro Effect of Cytokines, Inducers, and Inhibitors on the Secretion of MMP-2 and MMP-9 in Hepatocarcinoma Cell Line SK-Hep-1
(Gastrointestinal Cancers)
... remains dismal despite any treatment. Matrix metalloproteinases (MMPs) have been researched for their role in tumor invasion and metastasis. Various cytokines, mitogens, growth factors, inducers, and inhibitors ...
Created on 08 February 2020
79. Anti-borreliae Efficacy of Volatile and Non-volatile Organic Oils and Lipids
(Scientific Presentations: Infectious Diseases)
... (sweet birch oil, laurel leaf oil, chamomile oil) revealed their bactericidal activity against typical motile spirochetes at or below 1.0% concentration. The same agents exhibited similar bactericidal ...
Created on 07 December 2019
80. Anti-borreliae efficacy of selected organic oils and fatty acids
(Lyme Disease)
... Only Bay leaf oil and Cassia oil, including their major constituents, eugenol and cinnamaldehyde, showed to target biofilmlike aggregates of both tested Borrelia spp. at the same concentration, although ...
Created on 07 December 2019