Total: 100 results found.

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61. Natural Compounds Modulate Apolipoprotein E Gene and Protein Expression in Fibroblasts Derived from Young and Old Female Alzheimer’s Patients
(New Publications)
... APOE gene transcription as well as APOE, APOE4, and Tau proteins expression in cells cultured in non-inflammatory and pro-inflammatory conditions. The study was conducted on fibroblasts derived from ...
Created on 22 May 2024
62. L-lysine and vitamin C work better in synergy against Escherichia coli and Acinetobacter baumanniis
(New Publications)
... their specific combinations, that allow for simultaneously affecting cellular mechanisms of interest and increasing efficacy at lower doses than individual compounds. Here we present results of the study ...
Created on 27 October 2023
63. Inhibitory effect of theaflavin-3,30 -digallate can involve its binding to the “stem” domain of α-hemolysin of Staphylococcus aureus
(New Publications)
... In this study we examined the mode of antihemolytic activity of theaflavin-3,3′-digallate against α-hemolysin of methicillin-resistant S. aureus by molecular docking using AutoDock Vina as the molecular ...
Created on 27 October 2023
64. Inhibition of α-hemolysin activity of Staphylococcus aureus by theaflavin 3,3’-digallate
(New Publications)
...  Here, we set out to examine mechanisms by which theaflavin 3,3’-digallate (TF3) might act as an anti-hemolytic compound. In the presented study, we found that TF3 has weak bacterio-static and bactericidal ...
Created on 06 September 2023
65. Phytochemicals and micronutrients in suppressing infectivity caused by SARS-CoV-2 virions and seasonal coronavirus HCoV-229E in vivo
(New Publications)
... study implying a wave of new mutants in vaccinated people making them more susceptible to the newest variants and fueling a rapid viral evolution, there is a need for alternative or adjunct approaches ...
Created on 02 June 2023
66. Cellular effects of fruit extracts and their active components applied individually and in combinations
(New Publications)
... all touting various health benefits. However, the efficacy of these blends is rarely reported or studied. Methods and results: In our study, we scientifically evaluated some cellular effects of a mix ...
Created on 28 February 2023
67. Cellular effects of citrus compounds
(Others)
... and food products. However, there are no systematic studies comparing their efficacy at a cellular level. Methods and results: In this study, we evaluated the efficacy of select citrus fruit extracts ...
Created on 04 January 2023
68. Linoleic acid binds to SARS‑CoV‑2 RdRp and represses replication of seasonal human coronavirus OC43
(Coronavirus)
... bond with Lys593 and Asp865. In line with these results, a dose-dependent inhibition of HCoV-OC43 replication in vitro was observed, additionally strengthened by data from in vivo study, which also confirmed ...
Created on 16 November 2022
69. Inhibition of Borrelia Burgdorferi-Induced TLR2-NFκB Canonical Signaling by Gallic Acid through Targeting the CD14+ Adaptor Protein and p65 Molecule
(Lyme Disease)
Goc A, Rath M, Niedzwiecki A. International Journal of Molecular Science 2022, 23, 10987. https://doi.org/10.3390/ijms231910987 Abstract: The cases of Lyme disease caused by Borrelia burgdorferi infection ...
Created on 26 September 2022
70. Composition of naturally occurring compounds decreases activity of Omicron and SARS-CoV-2 RdRp complex
(Coronavirus)
... of recombinant RdRp complex to individual compounds of this composition pointed to quercetin as the driving inhibitory compound. The outcome of this study supports the motion of antiviral efficacy of natural ...
Created on 24 August 2022
71. Inhibitory effects of specific combination of natural compounds against SARS-CoV-2 and its Alpha, Beta, Gamma, Delta, Kappa, and Mu variants
(Coronavirus)
... key cellular mechanisms of viral infectivity. In this study, we evaluated the efficacy of a defined mixture of plant extracts and micronutrients against original SARS-CoV-2 and its Alpha, Beta, Gamma, ...
Created on 18 August 2022
72. Health Benefits of Specific Micronutrient Combinations in Diabetes
(Diabetes)
... superior synergetic effects of these bioactive molecules in the prevention and therapy of diabetes.   Our study shows that specific combinations of vitamins, minerals and other active plant derived ...
Created on 31 March 2022
73. Age and Dietary Vitamin C Intake Affect Brain Physiology in Genetically Modified Mice Expressing Human Lipoprotein(A) and Unable to Synthesize Vitamin C
(Aging)
... transgenic mouse, Gulo (-/-); Lp(a)+, presents a unique model for the study of key aspects of human metabolism with respect to a lack of internal vitamin C synthesis and the production of human lipoprotein(a). ...
Created on 24 December 2021
74. Simultaneous Inhibition of SARS-CoV-2 Infectivity by a Specific Combination of Plant-derived Compounds
(Coronavirus)
... activity, but modestly decrease cellular expression of neuropilin-1 molecule and significantly inhibited activity of viral RdRp. This study demonstrates inhibitory effects of this combination ...
Created on 23 September 2021
75. Dietary Vitamin C and Age-Induced Lipid and Hormonal Metabolic Changes in a Humanized Mouse Model Not Synthesizing Vitamin C and Producing Lipoprotein(a) [Gulo (−/−); Lp(a)+]
(Aging)
... suitable for the study of metabolic aspects relevant to human metabolism. It is a well-known fact that vitamin C is essential in collagen synthesis, and in maintaining extracellular matrix integrity, as ...
Created on 23 June 2021
76. Phenolic compounds disrupt spike-mediated receptor-binding and entry of SARS-CoV-2 pseudo-virions
(Coronavirus)
... same time its activity in both cell-free and cell-based assays. Our study also demonstrates that brazilin and theaflavin-3,3’-digallate, and to a still greater extent, curcumin, decrease the activity of ...
Created on 22 June 2021
77. Micronutrients in mitigating the adverse health effects of air pollution – part 2
(Others)
W. Sumera, M.Sc. Journal of Cellular Medicine and Natural Health, July 2018   Abstract: Air pollution is a major environmental risk to human health and well-being. According to WHO reports in 2012, ...
Created on 11 June 2021
78. Simultaneous inhibition of key mechanisms of SARS-CoV-2 infectivity by a specific combination of polyphenols
(Scientific Presentations: Infectious Diseases)
... activity, but modestly decrease cellular expression of neuropilin-1 molecule and significantly inhibited activity of viral RdRp. This study demonstrates inhibitory effects of this combination on key cellular ...
Created on 14 May 2021
79. Anti-borreliae efficacy of Gallic acid in vitro
(Scientific Presentations: Infectious Diseases)
... still sought after due to the growing number of newly infected patients or those that relapse after discontinuation of antibiotic application. In this study, we investigated whether a trihydroxybenzoic ...
Created on 12 May 2021
80. Polyunsaturated ω‑3 fatty acids inhibit ACE2‑controlled SARS‑CoV‑2 binding and cellular entry
(Coronavirus)
... Although further in vivo experiments are warranted to validate the current fndings, our study provides a new insight into the role of lipids as antiviral compounds against the SARS-CoV-2 strain.   ...
Created on 05 May 2021