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81. Anti-Atherogenic Effects of a Mixture of Ascorbic Acid, Lysine, Proline, Arginine, Cysteine, and Green Tea Phenolics in Human Aortic Smooth Muscle Cells
(Heart Disease)
... and increased secretion of inflammatory cytokines as a response to inflammatory stimuli. We investigated the anti-atherogenic effects of naturally occuring compounds (ascorbic acid, green tea extract, ...
Created on 14 March 2015
82. Anticancer Effects of a Micronutrient Mixture on Melanoma: Modulation of Metastasis and Other Critical Parameters
(Skin Cancer)
... on using specific natural components, among them  lysine, proline, ascorbic acid and green tea extract (NM). We have documented synergistic effects of this micronutrient mixture and its effectiveness in ...
Created on 08 March 2015
83. Antineoplastic effects of nutrient mixture on raji and jurkat T cells: the two highly aggressive Non-Hodgkin's Lymphoma cell line
(Blood Cancer)
... higher relapse rate, and treatment complications pose significant barriers. Decreased food intake and side effects of treatments make cancer patients vulnerable to deficiency of essential nutrients such ...
Created on 08 March 2015
84. Inhibitory effects of a novel nutrient mixture on MMP secretion and invasion on human thyroid cancer cell line SW 579
(Head & Neck Cancers)
M.W. Roomi, B. Bhanap, A. Niedzwiecki, and M. Rath JANA 2009, 13(1): 26-34 Abstract:  Thyroid cancer is the most common endocrine malignancy. Mortality from thyroid cancer results from tumor invasion ...
Created on 07 March 2015
85. Anticancer Effects of a Specific Mixture of Nutrients in Multidrug Resistant Human Uterine Sarcoma Cell Line MES-SA/Dx5 and in Drug Sensitive MES-SA Cell Line
(Female Reproductive Cancer)
... was to investigate the comparative effects of NM on anticancer parameters such as cytotoxicity, MMP secretion, and Matrigel invasion in the human uterine sarcoma drug-resistant MES-SA/Dx5 and drug sensitive ...
Created on 07 March 2015
86. Effects of a nutrient mixture on immunohistochemical localization of cancer markers in human cervical cancer HeLa cell tumor xenografts in female nude mice
(Female Reproductive Cancer)
M.W. Roomi, T. Kalinovsky, J. Cha, N.M. Roomi,  A. Niedzwiecki and M. Rath Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050 Experimental & Therapeutic Medicine 2014, DOI: 10.3892/etm.2014.2127 ...
Created on 07 March 2015
87. Antiangiogenic Effects of a Nutrient Mixture on Human Umbilical Vein Endothelial Cells
(Angiogenesis)
... has antiangiogenic effects on human umbilical vein endothelial cells (HUVECs).    Methods: At near confluence, the HUVEC cell cultures were tested with NM at 0, 10, 50, 100, 500, and 1000 µg/ml in ...
Created on 07 March 2015
88. Comparative Effects of EGCG, Green Tea, and a Nutrient Mixture on the Patterns of MMP-2 and MMP-9 Expression in Cancer Cell Lines
(MMP)
M.W. Roomi, J.C. Monterrey, T. Kalinovsky, M. Rath and A. Niedzwiecki Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050 Onc Rep 2010, 24: 747-757 Abstract Type IV collagenase matrix ...
Created on 07 March 2015
89. In vivo and in vitro effects of a nutrient mixture on breast 4T1 cancer progression
(Breast Cancer)
M.W. Roomi, T. Kalinovsky, N.M. Roomi, J. Cha, M. Rath, A. Niedzwiecki Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050 International Journal of Oncology 2014, DOI: 10.3892/ijo.2014.2379 ...
Created on 07 March 2015
90. Inhibitory Effects of a Nutrient Mixture on Human Testicular Cancer Cell Line NT 2/DT Matrigel Invasion and MMP Activity
(Testicular Cancer)
M.W. Roomi, V. Ivanov, T. Kalinovsky, A. Niedzwiecki, M. Rath Medical Oncology 2007, 24(2): 183-188 Abstract: Current treatment of testicular cancer is associated with secondary malignancy, infertility, ...
Created on 07 March 2015
91. Health Protective Effects Of Phytonutrients: Quercetin
(Health Science News Page)
... for maintaining strong blood vessels and it can decrease the thickness of the blood, which could prevent blood clots. It can protect the liver and can counteract dangerous effects of artificial estrogen. ...
Created on 27 February 2015
92. In vivo and in vitro antitumor effects of nutrient mixture in murine leukemia cell line P-388
(Blood Cancer)
... in triplicates. The effects were evaluated by cell proliferation, Matrigel invasion, cell morphology and apoptosis. The in vivoeffect was measured in male nude mice (n = 12) inoculated with P-388 cells. ...
Created on 21 January 2011
93. Natural Compounds Modulate Apolipoprotein E Gene and Protein Expression in Fibroblasts Derived from Young and Old Female Alzheimer’s Patients
(New Publications)
... disease cases. Targeting the APOE gene with nutrients and natural compounds could potentially benefit Alzheimer’s disease patients. In the search for such natural-derived compounds, we evaluated the effects ...
Created on 22 May 2024
94. Inhibition of α-hemolysin activity of Staphylococcus aureus by theaflavin 3,3’-digallate
(New Publications)
... effects on Staphylococcus aureus, and strong inhibitory effect towards the hemolytic activity of its α-hemolysin (Hla) including its production and secretion. A supportive SPR assay reinforced these results ...
Created on 06 September 2023
95. Inhibition of Borrelia Burgdorferi-Induced TLR2-NFκB Canonical Signaling by Gallic Acid through Targeting the CD14+ Adaptor Protein and p65 Molecule
(Lyme Disease)
... novel agents against B. burgdorferi, we investigated a phenolic compound—gallic acid—for its anti-Borrelia and anti-inflammatory effects. Our results showed its biocidal effect starting from 100 μg/mL ...
Created on 26 September 2022
96. Composition of naturally occurring compounds decreases activity of Omicron and SARS-CoV-2 RdRp complex
(Coronavirus)
... it more difficult for an infectious agent to evade all these mechanisms at the same time. Considering the urgency in finding effective prevention, but also side-effects free treatment of COVID-19 our results ...
Created on 24 August 2022
97. Health Benefits of Specific Micronutrient Combinations in Diabetes
(Diabetes)
... certain plant extracts (micronutrients) have been studied for their effects on diabetic metabolism. These studies, however, were largely conducted with individual micronutrients, thereby neglecting the ...
Created on 31 March 2022
98. Age and Dietary Vitamin C Intake Affect Brain Physiology in Genetically Modified Mice Expressing Human Lipoprotein(A) and Unable to Synthesize Vitamin C
(Aging)
...  Methods: This mouse model was used in our study to investigate the effects of prolonged intake of low and high levels of vitamin C, at different ages, on oxidative damage, cholesterol levels and lipoprotein(a) ...
Created on 24 December 2021
99. Simultaneous Inhibition of SARS-CoV-2 Infectivity by a Specific Combination of Plant-derived Compounds
(Coronavirus)
... activity, but modestly decrease cellular expression of neuropilin-1 molecule and significantly inhibited activity of viral RdRp. This study demonstrates inhibitory effects of this combination ...
Created on 23 September 2021
100. Dietary Vitamin C and Age-Induced Lipid and Hormonal Metabolic Changes in a Humanized Mouse Model Not Synthesizing Vitamin C and Producing Lipoprotein(a) [Gulo (−/−); Lp(a)+]
(Aging)
... well as being a powerful antioxidant and cofactor in many metabolic pathways, which makes it a critically important micronutrient for health and healthy aging. In this study, we investigated the effects ...
Created on 23 June 2021