Induction of Apoptosis in Human Lung Cancer Cells (A-549) by a Novel Nutrient Mixture via Upregulation of Caspase Enzymes
M.W. Roomi, Ph.D., Ahmed T, A. Niedzwiecki, Ph.D., M. Rath, M.D.
Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050
Austin J Lung Cancer Res. 2018; 3(1): 1013 – 1016
Abstract:
Peptide vaccines directed against human Metalloproteinases (MMPs) with anti-tumor efficacy in vitro and in vivo
M.W. Roomi, Ph.D., A. Niedzwiecki, Ph.D., M. Rath, M.D.
Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050
Journal of Cellular Medicine and Natural Health
Abstract:
Despite sporadic progress, cancer has thus far eluded preventive and therapeutic approaches that can lead to an effective control of this global epidemic. The single most important reason for this failure is the fact that no effective intervention became available to impede the pathological pathways common to all types of cancer. In our study, we targeted metalloproteinases (MMPS), endopeptidases that are involved in the breakdown of extracellular matrix (ECM). Among them, MMP-2 and MMP-9 are critically involved in all stages of cancer development including tumor growth, invasion and metastasis.
Our goal was to develop an anti-cancer vaccine by inhibiting these specific enzymes. We selected three oligopeptides from human MMP-9 and one from human MMP-2. We demonstrated the efficacy of these oligopeptides in generating immune response in mice. The in vitro tests showed that anti-MMPs sera were effective in curbing invasion of HeLA cells through the extracellular matrix system (Matrigel).
Read more ...Down regulation of u-Pa by a nutrient mixture In hemangioma (eoma) cells by inducing Caspase-dependent apoptosis
M.W. Roomi, T. Kalinovsky, M. Rath, A. Niedzwiecki
Oncology Division, Dr. Rath Research Institute,1260 Memorex Drive, Santa Clara, CA 95050
Nutraceuticals – Efficacy, Safety and Toxicity, ed. R.C. Gupta, Elsevier 2016, pp 135-144
Abstract:
Hemangiomas are the most common congenital vascular and benign tumor in infants and children. Most hemangiomas do not cause major symptoms to require intervention, however, the larger hemangiomas have tendency to bleed and may require surgical removal. Experimental studies have demonstrated the role of urokinase plasminogen activator (u-PA), especially cell surface u-PA, as an initiator of extra-cellular matrix proteolysis and associated tumor cell invasion.
Anticancer Efficacy Of Polyphenols And Their Combinations
Aleksandra Niedzwiecki, Mohd Waheed Roomi, Tatiana Kalinovsky, Matthias Rath
Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050
Nutrients 2016, 8, 552; DOI: 10.3390/nu8090552
Abstract:
Polyphenols, found abundantly in plants, display many anticarcinogenic properties including their inhibitory effects on cancer cell proliferation, tumor growth, angiogenesis, metastasis, and inflammation as well as inducing apoptosis. In addition, they can modulate immune system response and protect normal cells against free radical damage. Most investigations on anticancer mechanisms of polyphenols were conducted with individual compounds. However, several studies, including ours, have indicated that anti-cancer efficacy and scope of action can be further enhanced by combining them synergistically with chemically similar or different compounds. While most studies investigated the anti-cancer effects of combinations of two or three compounds, we used more comprehensive mixtures of specific polyphenols and mixtures of polyphenols with vitamins, amino acids and other micronutrients.
Nutraceuticals In Cancer Prevention(Chapter 11)
M.W. Roomi, T. Kalinovsky, M. Rath, A. Niedzwiecki
Dr. Rath Research Institute,1260 Memorex Drive, Santa Clara, CA 95050
Nutraceuticals – Efficacy, Safety and Toxicity, ed. R.C. Gupta, Elsevier 2016, pp 135-144
Abstract:
The mainstays of cancer treatment are surgery, chemotherapy, radiation and immunotherapy. Although each has benefits, none of them is ideal, because with all these strategies the quality of life is compromised. Therefore, it is not surprising that 80% of cancer patients seek alternative therapy, which includes antioxidants and other essential micronutrients. We have developed new approaches to prevent cancer development, progression and metastasis using naturally occurring micronutrients containing lysine, proline, ascorbic acid and green tea extract (NM) that act synergistically by strengthening collagen and connective tissue.
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